Samatasvir
Modify Date: 2023-01-14 19:21:28
Samatasvir structure
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Common Name | Samatasvir | ||
|---|---|---|---|---|
| CAS Number | 1312547-19-5 | Molecular Weight | 885.064 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C47H48N8O6S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SamatasvirSamatasvir (IDX719) is a highly potent, selective inhibitor of HCV NS5A that effectively inhibits HCV genotype 1-5 replicons with EC50 of 2-24 pM; also retains full activity in the presence of HIV and hepatitis B virus (HBV) antivirals; demonstrates an overall additive effect when combined with IFN-α, ribavirin, representative HCV protease, and nonnucleoside polymerase inhibitors or the nucleotide prodrug IDX184. HCV Infection Phase 2 Clinical |
| Name | samatasvir |
|---|---|
| Synonym | More Synonyms |
| Description | Samatasvir (IDX719) is a highly potent, selective inhibitor of HCV NS5A that effectively inhibits HCV genotype 1-5 replicons with EC50 of 2-24 pM; also retains full activity in the presence of HIV and hepatitis B virus (HBV) antivirals; demonstrates an overall additive effect when combined with IFN-α, ribavirin, representative HCV protease, and nonnucleoside polymerase inhibitors or the nucleotide prodrug IDX184. HCV Infection Phase 2 Clinical |
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| References | References 1. Bilello JP, et al. Antimicrob Agents Chemother. 2014 Aug;58(8):4431-42. 2. Vince B, et al. J Hepatol. 2014 May;60(5):920-7. View Related Products by Target HCV HCV Infection |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C47H48N8O6S2 |
| Molecular Weight | 885.064 |
| Exact Mass | 884.313843 |
| LogP | 10.30 |
| Index of Refraction | 1.675 |
| Carbamic acid, N-[(1R)-2-[(2S)-2-[4-[4-[6-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-1H-benzimidazol-5-yl]thieno[3,2-b]thien-3-yl]phenyl]-1H-imidazol-2-yl]-1-pyrrolidinyl]-2-oxo-1-phenylethyl]-, methyl ester |
| Methyl {(1R)-2-[(2S)-2-{4-[4-(6-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-pyrrolidinyl]-1H-benzimidazol-5-yl}thieno[3,2-b]thiophen-3-yl)phenyl]-1H-imidazol-2-yl}-1-pyrrolidinyl]-2-oxo-1-phenylethyl}carbamate |
| samatasvir |
| IDX18719 |