HPPE
Modify Date: 2025-08-24 19:22:04
HPPE structure
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Common Name | HPPE | ||
|---|---|---|---|---|
| CAS Number | 1325721-55-8 | Molecular Weight | 479.478 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H20F3N5O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HPPEHPPE is a specific nonelectrophilic and physiological Bach1 inhibitor via heme-binding sites of Bach1 protein, derepresses Bach1-mediated repression.HPPE induces up-regulation of Hmox1 mRNA is mediated by Bach1 inhibition in vivo.Nuclear export of Bach1 is required for HPPE-mediated Bach1 derepression, HPPE has an additional activity in Nrf2 stabilization besides Bach1 inhibition.Pre- and posttreatment of HPPE is neuroprotective against acute MPTP neurotoxicity.HPPE significantly reduced MPTP-induced increases in TNF-α and Mcp-1 mRNA levels, HPPE significantly increased mRNA levels of Nrf2 compared to MPTP-treated mice that received the vehicle.Bach1 is a known transcriptional repressor of the Nrf2 pathway.Bach1 ablation is cytoprotective, as it suppresses reactive oxygen species (ROS) generation, mitigates excessive inflammation, improves mitochondrial function, and inhibits apoptosis. |
| Name | HPPE |
|---|
| Description | HPPE is a specific nonelectrophilic and physiological Bach1 inhibitor via heme-binding sites of Bach1 protein, derepresses Bach1-mediated repression.HPPE induces up-regulation of Hmox1 mRNA is mediated by Bach1 inhibition in vivo.Nuclear export of Bach1 is required for HPPE-mediated Bach1 derepression, HPPE has an additional activity in Nrf2 stabilization besides Bach1 inhibition.Pre- and posttreatment of HPPE is neuroprotective against acute MPTP neurotoxicity.HPPE significantly reduced MPTP-induced increases in TNF-α and Mcp-1 mRNA levels, HPPE significantly increased mRNA levels of Nrf2 compared to MPTP-treated mice that received the vehicle.Bach1 is a known transcriptional repressor of the Nrf2 pathway.Bach1 ablation is cytoprotective, as it suppresses reactive oxygen species (ROS) generation, mitigates excessive inflammation, improves mitochondrial function, and inhibits apoptosis. |
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| References | 1. Manuj Ahuja, et al. Proc Natl Acad Sci U S A. 2021 Nov 9;118(45):e2111643118. |
| Molecular Formula | C21H20F3N5O3S |
|---|---|
| Molecular Weight | 479.478 |
| InChIKey | BJSHVWKLYLAKTP-UHFFFAOYSA-N |
| SMILES | Cn1c(Nc2nc3ccc(C(F)(F)F)cc3s2)nc2cc(C(=O)NCCOCCO)ccc21 |