2-Diethylaminoethyl 4-amino-2-chloro-benzoate

Modify Date: 2024-01-01 21:08:51

2-Diethylaminoethyl 4-amino-2-chloro-benzoate structure	Common Name	2-Diethylaminoethyl 4-amino-2-chloro-benzoate
	CAS Number	133-16-4	Molecular Weight	307.21600
	Density	1.17g/cm3	Boiling Point	402.6ºC at 760mmHg
	Molecular Formula	C₁₃H₂₀Cl₂N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	197.3ºC

Use of 2-Diethylaminoethyl 4-amino-2-chloro-benzoate

Chloroprocaine (2-Chloroprocaine) is a potent inhibitor of Na,K-ATPase activity with an IC50 of 13 mM. Chloroprocaine blocks peripheral nerve[1].

Name	chloroprocaine
Synonym	More Synonyms

Description	Chloroprocaine (2-Chloroprocaine) is a potent inhibitor of Na,K-ATPase activity with an IC50 of 13 mM. Chloroprocaine blocks peripheral nerve[1].
Target	IC50: 13 mM (Na,K-ATPase)[1]
In Vivo	In mice, the intravenous LD50 of Chloroprocaine HCl is 97 mg/kg and the subcutaneous LD50 of Chloroprocaine HCl is 950 mg/kg[2].
References	[1]. H Kutchai, et al. Inhibition of the Na,K-ATPase of Canine Renal Medulla by Several Local Anesthetics. Pharmacol Res. 2001 Apr;43(4):399-403. [2]. Chloroprocaine HCl Injection.

Density	1.17g/cm3
Boiling Point	402.6ºC at 760mmHg
Molecular Formula	C₁₃H₂₀Cl₂N₂O₂
Molecular Weight	307.21600
Flash Point	197.3ºC
Exact Mass	306.09000
PSA	55.56000
LogP	3.80400
Vapour Pressure	1.08E-06mmHg at 25°C
Index of Refraction	1.553

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG1575100

CHEMICAL NAME :: Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester

CAS REGISTRY NUMBER :: 133-16-4

BEILSTEIN REFERENCE NO. :: 2808071

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H19-Cl-N2-O2

MOLECULAR WEIGHT :: 270.79

WISWESSER LINE NOTATION :: ZR CG DVO2N2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 64 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 3,525,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9329 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 48 (estimated) No. of Female Employees: 48 (estimated)

HS Code	2922499990

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

2-(diethylamino)ethyl 4-amino-2-chlorobenzoate

Chloroprocainum

Piocaine

Chloroprocain

Nesacaine

Chlorprocain

2-Chloroprocaine

Halestyn

Chlorprocainum

Chlorprocaine

CHLOROPROCAINE

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Diethylaminoethyl 4-amino-2-chloro-benzoate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Use of 2-Diethylaminoethyl 4-amino-2-chloro-benzoate

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