o-Iodohippurate sodium

Modify Date: 2024-01-11 11:16:26

o-Iodohippurate sodium Structure
o-Iodohippurate sodium structure
 Common Name o-Iodohippurate sodium
CAS Number 133-17-5 Molecular Weight 327.05100
Density N/A Boiling Point 480.9ºC at 760mmHg
Molecular Formula C9H7INNaO3 Melting Point N/A
MSDS N/A Flash Point 244.6ºC

 Use of o-Iodohippurate sodium


o-Iodohippurate sodium is an analogue of p-aminohippuric acid for the determination of effective renal plasma flow. Labelled OIH has a significantly higher clearance than other radiopharmaceutical yet developed and is eminently suitable for renography. It is eliminated mainly by tubular secretion. In patients with normally functioning kidneys, 85% of the OIH may be found in the urine 30 minutes after intravenous injection.

 Names

Name sodium o-iodohippurate
Synonym More Synonyms

 Chemical & Physical Properties

Boiling Point 480.9ºC at 760mmHg
Molecular Formula C9H7INNaO3
Molecular Weight 327.05100
Flash Point 244.6ºC
Exact Mass 326.93700
PSA 69.23000
LogP 0.16180
Vapour Pressure 4.67E-10mmHg at 25°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MR8162000
CHEMICAL NAME :
Hippuric acid, o-iodo-, monosodium salt
CAS REGISTRY NUMBER :
133-17-5
LAST UPDATED :
199309
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C9-H7-I-N-O3.Na
MOLECULAR WEIGHT :
327.06
WISWESSER LINE NOTATION :
OVIMVR BI &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 116,394,1956
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 42,721,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MECHAN Medicinal Chemistry, A Series of Reviews. (New York, NY) V.1-6, 1951-63. Discontinued. Volume(issue)/page/year: 6,290,1963

 Synonyms

hippuran
jodairol
iodohippura
medopaque
Sodium iodohippurate
EINECS 205-097-5
iodairal
renumbral
orthoiodin
iodohippuratesodium
hippodin
urocontrast
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