PERK-IN-6

Modify Date: 2025-12-01 19:29:01

PERK-IN-6 structure	Common Name	PERK-IN-6
	CAS Number	1337532-14-5	Molecular Weight	398.46
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₂N₆O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PERK-IN-6

PERK-IN-6 (Compound 5) is a PERK inhibitor with an IC50 of 2.5 nM[1].

Name	PERK-IN-6

Description	PERK-IN-6 (Compound 5) is a PERK inhibitor with an IC50 of 2.5 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> PERK
Target	IC50: 2.5 nM (PERK)[1]
In Vitro	在 A549 细胞中，PERK-IN-6 (Compound 5) 抑制 thapsigargin 诱导的 PERK 自磷酸化，IC50 为 0.1-0.3 μΜ[1]。
In Vivo	SD 大鼠静脉注射 PERK-IN-6 (Compound 5) 后血液清除率为 10.5 mL/min/kg [1]。
References	[1]. Axten JM, et al. Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development. ACS Med Chem Lett. 2013 Aug 12;4(10):964-8.

Molecular Formula	C₂₃H₂₂N₆O
Molecular Weight	398.46
InChIKey	VYZYOJULVVGQRS-UHFFFAOYSA-N
SMILES	Cc1cccc(CC(=O)N2CCc3cc(-c4cn(C)c5ncnc(N)c45)ccc32)n1

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PERK-IN-6
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