AS1928370
Modify Date: 2024-04-05 13:44:44
AS1928370 structure
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Common Name | AS1928370 | ||
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| CAS Number | 1345614-89-2 | Molecular Weight | 453.586 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H31N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AS1928370AS1928370 (ASP8370) is a potent, selective, orally available TRPV1 antagonist with IC50 of 0.51 uM, shows no inhibitory effects on TRPV4, TRPA11, and TRPM8 at 10 uM; demonstrates high aqueous solubility (pH6.8, >100 uM), satisfactory stability in human liver microsomes, and reduced CYP3A4 inhibition; improves capsaicin-induced secondary hyperalgesia and mechanical allodynia in an L5/L6 spinal nerve ligation model in rats with respective ED50s of 0.17 and 0.26 mg/kg p.o. |
| Name | AS1928370 |
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| Description | AS1928370 (ASP8370) is a potent, selective, orally available TRPV1 antagonist with IC50 of 0.51 uM, shows no inhibitory effects on TRPV4, TRPA11, and TRPM8 at 10 uM; demonstrates high aqueous solubility (pH6.8, >100 uM), satisfactory stability in human liver microsomes, and reduced CYP3A4 inhibition; improves capsaicin-induced secondary hyperalgesia and mechanical allodynia in an L5/L6 spinal nerve ligation model in rats with respective ED50s of 0.17 and 0.26 mg/kg p.o. |
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| References | References 1. Oka H, et al. Bioorg Med Chem. 2018 Jul 23;26(12):3716-3726. 2. Watabiki T, et al. J Pharmacol Exp Ther. 2011 Mar;336(3):743-50. 3. Watabiki T, et al. Biol Pharm Bull. 2011;34(7):1105-8. View Related Products by Target TRP Channel |
| Molecular Formula | C29H31N3O2 |
|---|---|
| Molecular Weight | 453.586 |