Olmesartan methyl ester

Modify Date: 2024-01-11 02:55:55

Olmesartan methyl ester Structure
Olmesartan methyl ester structure
Common Name Olmesartan methyl ester
CAS Number 1347262-29-6 Molecular Weight 460.528
Density 1.3±0.1 g/cm3 Boiling Point 712.0±70.0 °C at 760 mmHg
Molecular Formula C25H28N6O3 Melting Point N/A
MSDS N/A Flash Point 384.4±35.7 °C

 Use of Olmesartan methyl ester


Olmesartan methyl ester is an intermediate in the synthesis of Olmesartan medoxomil. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor antagonist with IC50 of 66.2 μM[1][2].

 Names

Name Methyl 4-(2-hydroxy-2-propanyl)-2-propyl-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carboxylate
Synonym More Synonyms

 Olmesartan methyl ester Biological Activity

Description Olmesartan methyl ester is an intermediate in the synthesis of Olmesartan medoxomil. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor antagonist with IC50 of 66.2 μM[1][2].
Related Catalog
References

[1]. Dimitrios Ntountaniotis, et al. An efficient synthetic method and theoretical calculations of olmesartan methyl ether: study of biological function of AT1 antagonism. Comb Chem High Throughput Screen. 2014;17(8):652-62.

[2]. Senda A, et al. Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8. Biol Pharm Bull. 2015;38(12):1975-9.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 712.0±70.0 °C at 760 mmHg
Molecular Formula C25H28N6O3
Molecular Weight 460.528
Flash Point 384.4±35.7 °C
Exact Mass 460.222290
LogP 4.03
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.645

 Synonyms

Methyl 4-(2-hydroxy-2-propanyl)-2-propyl-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carboxylate
MFCD24386461
1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, methyl ester
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