8-M-PDOT

Modify Date: 2025-08-25 11:36:47

8-M-PDOT structure	Common Name	8-M-PDOT
	CAS Number	134865-70-6	Molecular Weight	233.30600
	Density	1.09g/cm3	Boiling Point	447.8ºC at 760 mmHg
	Molecular Formula	C₁₄H₁₉NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	224.6ºC

Use of 8-M-PDOT

8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity[1][2].

Name	N-[(2R)-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl]propanamide
Synonym	More Synonyms

Description	8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Melatonin Receptor Signaling Pathways >> GPCR/G Protein >> Melatonin Receptor Research Areas >> Neurological Disease
Target	pKi: 8.23 (Melatonin MT2 receptor) and 8.95 (Melatonin MT1 receptor)[2]
In Vivo	8-M-PDOT (10 µg/µL; administrated into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) treatment shows anxiolytic-like effect[2]. Animal Model: Male Wistar rats (280-320 g) with Rotenone[2] Dosage: 10 µg/µL Administration: Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes Result: Increased percentage of time spent in the open arms and in the number of open arms entries.
References	[1]. Browning C, et al. Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors. Br J Pharmacol. 2000 Mar;129(5):877-86. [2]. Noseda AC, et al. REM sleep deprivation promotes a dopaminergic influence in the striatal MT2 anxiolytic-like effects. Sleep Sci. 2016 Jan-Mar;9(1):47-54.

Density	1.09g/cm3
Boiling Point	447.8ºC at 760 mmHg
Molecular Formula	C₁₄H₁₉NO₂
Molecular Weight	233.30600
Flash Point	224.6ºC
Exact Mass	233.14200
PSA	38.33000
LogP	2.46960
Vapour Pressure	3.27E-08mmHg at 25°C
Index of Refraction	1.542
InChIKey	RVIGBTUDFAGRTQ-UHFFFAOYSA-N
SMILES	CCC(=O)NC1CCc2cccc(OC)c2C1

Precursor 2
CAS#:123-62-6 Propionic anhydride CAS#:3880-76-0 5-HT1A modulato...
DownStream 0

8-methoxy-2-propionamidotetralin

Tocris-1035

8-M-PDOT

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China
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: AH-002
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Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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8-M-PDOT

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Precursor & DownStream

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