Sacibertinib

Modify Date: 2024-04-09 21:20:27

Sacibertinib structure	Common Name	Sacibertinib
	CAS Number	1351941-69-9	Molecular Weight	599.08
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₂H₃₁ClN₆O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Sacibertinib

Sacibertinib is a tyrosine kinase (Trk) inhibitor with EC50 value of 110 nM and 244 nM for EGFR-TK phosphorylation and HER2, respectively. Antineoplastic activity[1].

Name	Sacibertinib

Description	Sacibertinib is a tyrosine kinase (Trk) inhibitor with EC50 value of 110 nM and 244 nM for EGFR-TK phosphorylation and HER2, respectively. Antineoplastic activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR-TK phosphorylation:110 nM (EC50) HER2:244 nM (EC50)
In Vitro	Sacibertinib has inhibitory activity against Sk-Br-3, SW620 cells with GI50s of 3.8 nM and 1.78 μM, and against CCRF-CEM/T, Fadu, BxPc-3 and AsPC-1 with IC50s of 5.6 μM, 101 nM, 337 nM and 1 μM, respectively[1].
References	[1]. Hesheng Zhang, et al. Cyanoquinoline derivatives. CA2802130A1 (Example 138) [2]. International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 36, No. 2, 2022.

Molecular Formula	C₃₂H₃₁ClN₆O₄
Molecular Weight	599.08

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Sacibertinib
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Sacibertinib
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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