AQ-101
Modify Date: 2024-01-11 14:57:48
AQ-101 structure
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Common Name | AQ-101 | ||
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| CAS Number | 1353384-61-8 | Molecular Weight | 331.707 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 639.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C16H10ClNO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 340.7±31.5 °C | |
Use of AQ-101AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53; induces apoptosis of acute lymphoblastic leukemia (ALL) especially those with a wild-type p53 phenotype and MDM2 expression in vitro and in vivo; inhibits development of ALL in nude or SCID mice with a human ALL xenograft. |
| Name | 2-Chloro-N-(4,5-dihydroxy-9,10-dioxo-9,10-dihydro-2-anthracenyl)acetamide |
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| Synonym | More Synonyms |
| Description | AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53; induces apoptosis of acute lymphoblastic leukemia (ALL) especially those with a wild-type p53 phenotype and MDM2 expression in vitro and in vivo; inhibits development of ALL in nude or SCID mice with a human ALL xenograft. |
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| References | References 1. Gu L, et al. Mol Cancer Ther. 2018 Feb;17(2):497-507. View Related Products by Target MDM2-p53 |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 639.8±55.0 °C at 760 mmHg |
| Molecular Formula | C16H10ClNO5 |
| Molecular Weight | 331.707 |
| Flash Point | 340.7±31.5 °C |
| Exact Mass | 331.024750 |
| LogP | 4.36 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.749 |
| 2-Chloro-N-(4,5-dihydroxy-9,10-dioxo-9,10-dihydro-2-anthracenyl)acetamide |
| Acetamide, 2-chloro-N-(9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenyl)- |