Monomethyl auristatin E intermediate-7

Modify Date: 2024-04-11 16:28:41

Monomethyl auristatin E intermediate-7 Structure
Monomethyl auristatin E intermediate-7 structure
Common Name Monomethyl auristatin E intermediate-7
CAS Number 135383-55-0 Molecular Weight 365.46
Density N/A Boiling Point N/A
Molecular Formula C20H31NO5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Monomethyl auristatin E intermediate-7


Monomethyl auristatin E intermediate-7 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].

 Names

Name (3R,4S,5S)-tert-Butyl 4-(((benzyloxy)carbonyl)amino)-3-hydroxy-5-methylheptanoate

 Monomethyl auristatin E intermediate-7 Biological Activity

Description Monomethyl auristatin E intermediate-7 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
Related Catalog
References

[1]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.  

 Chemical & Physical Properties

Molecular Formula C20H31NO5
Molecular Weight 365.46
Storage condition Store at room temperature