PF05020182
Modify Date: 2023-10-18 20:25:15
PF05020182 structure
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Common Name | PF05020182 | ||
|---|---|---|---|---|
| CAS Number | 1354712-92-7 | Molecular Weight | 366.455 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C18H30N4O4 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of PF05020182PF05020182 is novel potent and selective Kv7.2/4 potassium channel opener. PF-05020182 (2) significantly inhibits convulsions in the MES assay at doses tested, consistent with in vitro activity measure. The physiochemical properties, in vitro and in vivo activities of PF-05020182 support further development as an adjunctive treatment of refractory epilepsy. Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in controlling spontaneous electrical activity during epileptic seizures. |
| Name | PF-05020182 |
|---|---|
| Synonym | More Synonyms |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Molecular Formula | C18H30N4O4 |
| Molecular Weight | 366.455 |
| Exact Mass | 366.226715 |
| LogP | 4.42 |
| Index of Refraction | 1.534 |
| RIDADR | NONH for all modes of transport |
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| N-[4,6-Dimethoxy-2-(4-methoxy-1-piperidinyl)-5-pyrimidinyl]-3,3-dimethylbutanamide |
| N-[4,6-Dimethoxy-2-(4-methoxy-1-piperidinyl)-5-pyrimidinyl]-3,3-dimethyl-butanamide |
| Butanamide, N-[4,6-dimethoxy-2-(4-methoxy-1-piperidinyl)-5-pyrimidinyl]-3,3-dimethyl- |
| PF-05020182 |