N-Palmitoyl Dopamine

Modify Date: 2024-01-11 09:45:50

N-Palmitoyl Dopamine structure	Common Name	N-Palmitoyl Dopamine
	CAS Number	136181-87-8	Molecular Weight	391.587
	Density	1.0±0.1 g/cm3	Boiling Point	589.5±40.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₄₁NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	310.3±27.3 °C

Use of N-Palmitoyl Dopamine

N-Palmitoyl dopamine (PALDA) is a endogenous, long-chain, linear fatty acid dopamide, which is inactive on TRPV1. N-Palmitoyl dopamine displays 'entourage' effects on endovanilloids N-arachidonoyl-dopamine (NADA) and anandamide[1].

Name	N-[2-(3,4-dihydroxyphenyl)ethyl]hexadecanamide
Synonym	More Synonyms

Description	N-Palmitoyl dopamine (PALDA) is a endogenous, long-chain, linear fatty acid dopamide, which is inactive on TRPV1. N-Palmitoyl dopamine displays 'entourage' effects on endovanilloids N-arachidonoyl-dopamine (NADA) and anandamide[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	PALDA (0.1-10 μM), the EC50 of N-arachidonoyl-dopamine (NADA) is lowered from approximately 90 to approximately 30 nM. The effect on intracellular Ca2+ by another endovanilloid, N-arachidonoyl-ethanolamine (anandamide, 50 nM), is also enhanced dose-dependently by PALDA. PALDA also acted in synergy with low pH (6.0-6.7) to enhance intracellular Ca2+ via TRPV1[1].
References	[1]. Luciano De Petrocellis, et al. Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels. Br J Pharmacol. 2004 Sep;143(2):251-6.

Density	1.0±0.1 g/cm3
Boiling Point	589.5±40.0 °C at 760 mmHg
Molecular Formula	C₂₄H₄₁NO₃
Molecular Weight	391.587
Flash Point	310.3±27.3 °C
Exact Mass	391.308655
PSA	69.56000
LogP	7.22
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.515