2'-THIOADENOSINE

Modify Date: 2024-01-14 09:04:40

2'-THIOADENOSINE structure	Common Name	2'-THIOADENOSINE
	CAS Number	136904-69-3	Molecular Weight	283.31
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₀H₁₃N₅O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 2'-THIOADENOSINE

2'-Thioadenosine (PD157432) is a selective and irreversible inhibitor of ErbB-1 and ErbB-2, with an IC50 of 45 µM for ErbB-2. 2'-Thioadenosine covalently inactivates ErbB-1 via modification of a cysteine residue at the active site[1].

Name	(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-sulfanyloxolan-3-ol
Synonym	More Synonyms

Description	2'-Thioadenosine (PD157432) is a selective and irreversible inhibitor of ErbB-1 and ErbB-2, with an IC50 of 45 µM for ErbB-2. 2'-Thioadenosine covalently inactivates ErbB-1 via modification of a cysteine residue at the active site[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	ErbB1 ErbB2:45 μM (IC50)
In Vitro	2'-Thioadenosine (50 µM) 对 FGF，PDGF 和胰岛素受体酪氨酸激酶没有活性[1]。 2'-Thioadenosine 使 ErbB-1 共价失活，这种失活可被 1 mM Dithiothreitol 逆转[1]。
References	[1]. Singh J, et, al. Structure-based design of a potent, selective, and irreversible inhibitor of the catalytic domain of the erbB receptor subfamily of protein tyrosine kinases. J Med Chem. 1997 Mar 28;40(7):1130-5.

Molecular Formula	C₁₀H₁₃N₅O₃S
Molecular Weight	283.31
Exact Mass	283.07400
PSA	158.11000

2'-Thioadenosine

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2'-THIOADENOSINE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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