2'-THIOADENOSINE
Modify Date: 2025-08-26 19:46:18
2'-THIOADENOSINE structure
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Common Name | 2'-THIOADENOSINE | ||
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| CAS Number | 136904-69-3 | Molecular Weight | 283.31 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H13N5O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 2'-THIOADENOSINE2'-Thioadenosine (PD157432) is a selective and irreversible inhibitor of ErbB-1 and ErbB-2, with an IC50 of 45 µM for ErbB-2. 2'-Thioadenosine covalently inactivates ErbB-1 via modification of a cysteine residue at the active site[1]. |
| Name | (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-sulfanyloxolan-3-ol |
|---|---|
| Synonym | More Synonyms |
| Description | 2'-Thioadenosine (PD157432) is a selective and irreversible inhibitor of ErbB-1 and ErbB-2, with an IC50 of 45 µM for ErbB-2. 2'-Thioadenosine covalently inactivates ErbB-1 via modification of a cysteine residue at the active site[1]. |
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| Related Catalog | |
| Target |
ErbB1 ErbB2:45 μM (IC50) |
| In Vitro | 2'-Thioadenosine (50 µM) 对 FGF，PDGF 和胰岛素受体酪氨酸激酶没有活性[1]。 2'-Thioadenosine 使 ErbB-1 共价失活，这种失活可被 1 mM Dithiothreitol 逆转[1]。 |
| References |
| Molecular Formula | C10H13N5O3S |
|---|---|
| Molecular Weight | 283.31 |
| Exact Mass | 283.07400 |
| PSA | 158.11000 |
| InChIKey | VLRCFULRQZKFRM-KQYNXXCUSA-N |
| SMILES | Nc1ncnc2c1ncn2C1OC(CO)C(O)C1S |
| 2'-Thioadenosine |