CO23
Modify Date: 2025-10-14 16:10:33
CO23 structure
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Common Name | CO23 | ||
|---|---|---|---|---|
| CAS Number | 1370363-74-8 | Molecular Weight | 592.17 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H18I2N2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CO23CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier[1]. |
| Name | CO23 |
|---|
| Description | CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier[1]. |
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| Related Catalog | |
| Target |
TRα[1] |
| In Vivo | CO23 (ip; 0.04-5.0 nmol/g) has ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses are equally effective. CO23 has no effect at the lowest dose of 0.04 nmol/g and increases Dio1 mRNA 5-, 10-, and 15-fold at the doses of 0.8, 2.5, and 5 nmol/g, respectively[1]. Animal Model: Hypothyroid Wistar rats[1] Dosage: 0.04, 0.8, 2.5, and 5.0 nmol/g Administration: Ip Result: Had ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses were equally effective. |
| References |
| Molecular Formula | C19H18I2N2O4 |
|---|---|
| Molecular Weight | 592.17 |
| InChIKey | JWJXVEFUJLKBBT-UHFFFAOYSA-N |
| SMILES | CC(C)c1cc(Oc2c(I)cc(CC3NC(=O)NC3=O)cc2I)ccc1O |