T2AA
Modify Date: 2024-04-06 18:23:58
T2AA structure
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Common Name | T2AA | ||
|---|---|---|---|---|
| CAS Number | 1380782-27-3 | Molecular Weight | 511.093 | |
| Density | 2.0±0.1 g/cm3 | Boiling Point | 568.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C15H15I2NO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 297.4±30.1 °C | |
Use of T2AAT2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase[1]. |
| Name | 4-{4-[(2S)-2-Amino-3-hydroxypropyl]-2,6-diiodophenoxy}phenol |
|---|---|
| Synonym | More Synonyms |
| Description | T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase[1]. |
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| Related Catalog | |
| In Vitro | T2AA(15 μM, 72 h) 抑制链间 DNA 交联（ICL）修复，它可以阻止作为 ICL 修复中间体形成的 DNA 双链断裂（DSB）的分解，具有抑制 DSB 修复的能力[1]。 |
| References |
| Density | 2.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 568.1±50.0 °C at 760 mmHg |
| Molecular Formula | C15H15I2NO3 |
| Molecular Weight | 511.093 |
| Flash Point | 297.4±30.1 °C |
| Exact Mass | 510.914124 |
| LogP | 3.44 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.715 |
| 4-{4-[(2S)-2-Amino-3-hydroxypropyl]-2,6-diiodophenoxy}phenol |
| Benzenepropanol, β-amino-4-(4-hydroxyphenoxy)-3,5-diiodo-, (βS)- |