Ribocil

Modify Date: 2024-01-14 22:46:23

Ribocil Structure
Ribocil structure
 Common Name Ribocil
CAS Number 1381289-58-2 Molecular Weight 382.483
Density 1.3±0.1 g/cm3 Boiling Point 610.4±65.0 °C at 760 mmHg
Molecular Formula C19H22N6OS Melting Point N/A
MSDS N/A Flash Point 323.0±34.3 °C

 Use of Ribocil


Ribocil is a highly selective chemical modulator of bacterial riboflavin riboswitches. Ribocil strongly inhibits GFP expression, achieving a 50% effective concentration (EC50) of 0.3 μM.Target: in vitro: Ribocil is a highly specific bioactive synthetic mimic of FMN, which competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB and inhibits bacterial growth. Ribocil-B demonstrates superior microbiological activity as compared to Ribocil-A (minimum inhibitory concentration (MIC) = 1 μg/ml versus MIC ≥ 64 μg/ml), inhibition of riboflavin synthesis (IC50 = 0.13 μM versus IC50 > 26 μM), and binding affinity to the E. coli FMN aptamer (Kd = 6.6 nM versus Kd ≥ 10,000 nM).[1]

 Names

Name Ribocil
Synonym More Synonyms

 Ribocil Biological Activity

Description Ribocil is a highly selective chemical modulator of bacterial riboflavin riboswitches. Ribocil strongly inhibits GFP expression, achieving a 50% effective concentration (EC50) of 0.3 μM.Target: in vitro: Ribocil is a highly specific bioactive synthetic mimic of FMN, which competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB and inhibits bacterial growth. Ribocil-B demonstrates superior microbiological activity as compared to Ribocil-A (minimum inhibitory concentration (MIC) = 1 μg/ml versus MIC ≥ 64 μg/ml), inhibition of riboflavin synthesis (IC50 = 0.13 μM versus IC50 > 26 μM), and binding affinity to the E. coli FMN aptamer (Kd = 6.6 nM versus Kd ≥ 10,000 nM).[1]
Related Catalog
References

[1]. Howe JA, et al. Selective small-molecule inhibition of an RNA structural element. Nature. 2015 Oct 29;526(7575):672-7.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 610.4±65.0 °C at 760 mmHg
Molecular Formula C19H22N6OS
Molecular Weight 382.483
Flash Point 323.0±34.3 °C
Exact Mass 382.157593
LogP 0.99
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.673
Storage condition 2-8℃

 Synonyms

4-Pyrimidinol, 2-[1-[[2-(methylamino)-5-pyrimidinyl]methyl]-3-piperidinyl]-6-(2-thienyl)-
2-(1-{[2-(Methylamino)-5-pyrimidinyl]methyl}-3-piperidinyl)-6-(2-thienyl)-4(1H)-pyrimidinone
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Related Compounds: More...
Ribocil-C
1825355-56-3
Ribocil B
1825355-55-2
Ribocil-C R enantiomer
2177266-81-6
Chemsrc provides Ribocil(CAS#:1381289-58-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Ribocil are included as well.>> amp version: Ribocil

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