mGlu5 PAM 4k

Modify Date: 2024-01-07 11:06:09

mGlu5 PAM 4k Structure
mGlu5 PAM 4k structure
Common Name mGlu5 PAM 4k
CAS Number 1382782-16-2 Molecular Weight 338.342
Density N/A Boiling Point N/A
Molecular Formula C18H15FN4O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of mGlu5 PAM 4k


A potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 130 nM; displays 50-fold selectivity over mGlu3, and no activity against mGlu1/2/4/6/7/8; shows antipsychotic-like activity in vivo and for treatment of schizophrenia.

 Names

Name mGlu5 PAM 4k

 mGlu5 PAM 4k Biological Activity

Description A potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 130 nM; displays 50-fold selectivity over mGlu3, and no activity against mGlu1/2/4/6/7/8; shows antipsychotic-like activity in vivo and for treatment of schizophrenia.
References References 1. Conde-Ceide S, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):429-434. View Related Products by Target mGluR

 Chemical & Physical Properties

Molecular Formula C18H15FN4O2
Molecular Weight 338.342
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