Rencofilstat
Modify Date: 2024-01-11 18:58:05
Rencofilstat structure
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Common Name | Rencofilstat | ||
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| CAS Number | 1383420-08-3 | Molecular Weight | 1303.784 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C67H122N12O13 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RencofilstatRencofilstat (CRV431) is a non-immunosuppressive analogue of cyclosporine A and pan-cyclophilin inhibitor, potently inhibits cyclophilin isoforms A, B, D, and G with IC50 of 1-7 nM.Rencofilstat (CRV431) is more than 13 times more potent than the parent compound, cyclosporine A (CsA).Rencofilstat (CRV431) inhibits liver HBV DNA and HBsAg, reduces liver HBV DNA levels and moderately decreased serum HBsAg levels in HBV transgenic mouse model.Rencofilstat (CRV431) shows potential as a drug candidate for chronic liver diseases. |
| Name | Rencofilstat |
|---|
| Description | Rencofilstat (CRV431) is a non-immunosuppressive analogue of cyclosporine A and pan-cyclophilin inhibitor, potently inhibits cyclophilin isoforms A, B, D, and G with IC50 of 1-7 nM.Rencofilstat (CRV431) is more than 13 times more potent than the parent compound, cyclosporine A (CsA).Rencofilstat (CRV431) inhibits liver HBV DNA and HBsAg, reduces liver HBV DNA levels and moderately decreased serum HBsAg levels in HBV transgenic mouse model.Rencofilstat (CRV431) shows potential as a drug candidate for chronic liver diseases. |
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| References | 1. Gallay P, et al. PLoS One. 2019 Jun 10;14(6):e0217433. 2. Kuo J, et al. J Pharmacol Exp Ther. 2019 Nov;371(2):231-241. 3. Trepanier DJ, et al. J Pharm Pharm Sci. 2018;21(1s):335s-348s. |
| Molecular Formula | C67H122N12O13 |
|---|---|
| Molecular Weight | 1303.784 |