| Description |
CYM 9484 is a selective and highly potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM[1].
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| Related Catalog |
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| Target |
NPYY2 receptor:19 nM (IC50)
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| In Vitro |
SF-11 is a selective, brain-penetrant NPY Y2 receptor antagonist with an IC50 value of 190 nM. Systematically explore the SAR of the hit molecule SF-11 that leads to the identification of selective and highly potent small molecule NPY Y2 receptor antagonist CYM 9484 (Compound 16). CYM 9484 is 10-fold more potent than the hit molecule SF-11. CYM 9484 is prepared by the coupling of α,α-diphenylpiperidino-4-methanol with a variety of aryl isothiocyanates[1].
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| References |
[1]. Mittapalli GK, et al. Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3916-20.
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