1-(2-chloroethyl)-1-nitroso-3-(2-norb-ornyl)urea

MOLECULAR FORMULA :

C10-H16-Cl-N3-O2

MOLECULAR WEIGHT :

245.74

WISWESSER LINE NOTATION :

L55 ATJ CMVNNO&2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

83 mg/kg

TOXIC EFFECTS :

Liver - jaundice, other or unclassified Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,372,1968

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

56 mg/kg

TOXIC EFFECTS :

Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,372,1968

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

54760 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

18750 ug/kg/15D-I

TOXIC EFFECTS :

Blood - normocytic anemia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :

NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,372,1968

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

15 mg/kg/5W-I

TOXIC EFFECTS :

Liver - change in gall bladder structure or function Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :

NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,372,1968

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Primate - monkey

DOSE/DURATION :

35 mg/kg/15D-I

TOXIC EFFECTS :

Liver - fatty liver degeneration Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,372,1968