CEP-37440
Modify Date: 2024-01-07 13:31:19
CEP-37440 structure
|
Common Name | CEP-37440 | ||
|---|---|---|---|---|
| CAS Number | 1391712-60-9 | Molecular Weight | 580.121 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C30H38ClN7O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CEP-37440CEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma).IC50 value: 2.3 nM (FAK); 120 nM (ALK cellular IC50 in 75% human plasma)Target: Dual FAK/ALKPreparation of fused bicyclic 2,4-diaminopyrimidine derivatives as a dual ALK and FAK inhibitorBy Jacobs, Martin J.; Ott, Gregory R. From PCT Int. Appl. (2013), WO 2013134353 A1 20130912. |
| Name | cep-37440 |
|---|---|
| Synonym | More Synonyms |
| Description | CEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma).IC50 value: 2.3 nM (FAK); 120 nM (ALK cellular IC50 in 75% human plasma)Target: Dual FAK/ALKPreparation of fused bicyclic 2,4-diaminopyrimidine derivatives as a dual ALK and FAK inhibitorBy Jacobs, Martin J.; Ott, Gregory R. From PCT Int. Appl. (2013), WO 2013134353 A1 20130912. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C30H38ClN7O3 |
| Molecular Weight | 580.121 |
| Exact Mass | 579.272461 |
| PSA | 114.88000 |
| LogP | 3.40 |
| Index of Refraction | 1.648 |
| Storage condition | 2-8℃ |
| 2-(5-chloro-2-{(S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-ylamino}pyrimidin-4-ylamino)-N-methylbenzamide |
| 2-[[5-chloro-2-[[(6S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5Hbenzo[7]annulen-2-yl]amino]pyrimidin-4-yl]amino]-N-methyl-benzamide |
| 2-{[5-Chloro-2-({(6R)-6-[4-(2-hydroxyethyl)-1-piperazinyl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl}amino)-4-pyrimidinyl]amino}-N-methylbenzamide |
| Benzamide, 2-[[5-chloro-2-[[(6R)-6,7,8,9-tetrahydro-6-[4-(2-hydroxyethyl)-1-piperazinyl]-1-methoxy-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-N-methyl- |
| Benzamide, 2-[[5-chloro-2-[[(6S)-6,7,8,9-tetrahydro-6-[4-(2-hydroxyethyl)-1-piperazinyl]-1-methoxy-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-N-methyl- |
| 2-[[5-chloro-2-[[(6S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]-amino]pyrimidin-4-yl]amino]-N-methylbenzamide |
| 2-{[5-Chloro-2-({(6S)-6-[4-(2-hydroxyethyl)-1-piperazinyl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl}amino)-4-pyrimidinyl]amino}-N-methylbenzamide |