Panamesine
Modify Date: 2024-01-13 16:04:20
Panamesine structure
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Common Name | Panamesine | ||
|---|---|---|---|---|
| CAS Number | 139225-22-2 | Molecular Weight | 426.46200 | |
| Density | 1.343g/cm3 | Boiling Point | 614.1ºC at 760 mmHg | |
| Molecular Formula | C23H26N2O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 325.2ºC | |
Use of PanamesinePanamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity (IC50 6 nM) and selectivity for sigma binding sites. Panamesine is a potential atypical neuroleptic agent[1]. |
| Name | (5S)-5-[[4-(1,3-benzodioxol-5-yl)-4-hydroxypiperidin-1-yl]methyl]-3-(4-methoxyphenyl)-1,3-oxazolidin-2-one |
|---|---|
| Synonym | More Synonyms |
| Description | Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity (IC50 6 nM) and selectivity for sigma binding sites. Panamesine is a potential atypical neuroleptic agent[1]. |
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| Related Catalog | |
| Target |
IC50: 6 nM (sigma receptor)[1] |
| In Vivo | Panamesine (EMD 57445; 0.3, 1, 3, 30 mg/kg) induces a dose-dependent increase of c-fos expression in several cortical areas with the strongest signals in the piriform cortex[1]. Animal Model: Female Sprague Dawley rats aged 2 months with a body weights of 200-250 g[1] Dosage: 0.3, 1, 3, 30 mg/kg Administration: Subcutanous injections Result: Specific c-fos gene expression was detected at all concentrations (0.3 mg/kg, 1 mg/kg, 3 mg/kg, 30 mg/kg) tested in frontal, parietal, perirhinal, temporal, piriform, insular, limbic, cingulate and occipital cortex. |
| References |
| Density | 1.343g/cm3 |
|---|---|
| Boiling Point | 614.1ºC at 760 mmHg |
| Molecular Formula | C23H26N2O6 |
| Molecular Weight | 426.46200 |
| Flash Point | 325.2ºC |
| Exact Mass | 426.17900 |
| PSA | 80.70000 |
| LogP | 2.73560 |
| Vapour Pressure | 6.17E-16mmHg at 25°C |
| Index of Refraction | 1.621 |
| Panamesine |
| (5S)-5-[(4-benzo[1,3]dioxol-5-yl-4-hydroxy-1-piperidyl)methyl]-3-(4-methoxyphenyl)oxazolidin-2-one |
| Panamesine [INN] |
| UNII-023D9E916L |