VU0424238
Modify Date: 2024-01-09 12:33:30
VU0424238 structure
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Common Name | VU0424238 | ||
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| CAS Number | 1396337-04-4 | Molecular Weight | 325.30 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H12FN5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of VU0424238VU0424238 is a novel and selective mGlu5 antagonist with an IC50 value of 11 nM (rat) and an IC50 value of 14 nM (human). VU0424238 has an acceptable CNS penetration[1]. |
| Name | N-(5-fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide |
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| Description | VU0424238 is a novel and selective mGlu5 antagonist with an IC50 value of 11 nM (rat) and an IC50 value of 14 nM (human). VU0424238 has an acceptable CNS penetration[1]. |
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| Related Catalog | |
| In Vitro | VU0424238 with an IC50 value of 14 nM in HEK293A cells. It also binding a known allosteric site with K i value of 4.4 nM in HEK293A cells. |
| In Vivo | VU0424238 had a clearance of 19.3 mL/min/kg in rats and demonstrates 50% mGlu5 PET ligand occupancy at an oral dose of 0.8 mg/kg in rats. Plus, it also had a clearance of 15.5 mL/min/kg in cynomolgus monkeys and demonstrates 50% mGlu5 PET ligand occupancy at an oral dose of 0.06 mg/kg in baboons[1]. |
| References |
| Molecular Formula | C16H12FN5O2 |
|---|---|
| Molecular Weight | 325.30 |
| Exact Mass | 325.09800 |
| PSA | 89.89000 |
| LogP | 2.83170 |
| Storage condition | 2-8℃ |