GSK2798745

Modify Date: 2025-08-23 21:28:08

GSK2798745 structure	Common Name	GSK2798745
	CAS Number	1419609-94-1	Molecular Weight	460.528
	Density	1.4±0.1 g/cm3	Boiling Point	682.1±65.0 °C at 760 mmHg
	Molecular Formula	C₂₅H₂₈N₆O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	366.3±34.3 °C

Use of GSK2798745

GSK2798745 is a first-in-class, highly potent, selective, orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker with IC50s of 1.8 and 1.6 nM for hTRPV4 and rTRPV4, respectively. GSK2798745 is used in research for the treatment of pulmonary edema associated with congestive heart failure[1][2].

Name	1-({(5S,7S)-3-[5-(2-Hydroxy-2-propanyl)-2-pyrazinyl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]dec-7-yl}methyl)-1H-benzimidazole-6-carbonitrile
Synonym	More Synonyms

Description	GSK2798745 is a first-in-class, highly potent, selective, orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker with IC50s of 1.8 and 1.6 nM for hTRPV4 and rTRPV4, respectively. GSK2798745 is used in research for the treatment of pulmonary edema associated with congestive heart failure[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cardiovascular Disease
Target	IC50: 1.8 nM (hTRPV4) and 1.6 nM (rTRPV4)[2]
References	[1]. Goyal N, et al. Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects. Am J Cardiovasc Drugs. 2019 Jun;19(3):335-342. [2]. Brooks CA, et al. Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4). ACS Med Chem Lett. 2019 Jul 15;10(8):1228-1233.

Density	1.4±0.1 g/cm3
Boiling Point	682.1±65.0 °C at 760 mmHg
Molecular Formula	C₂₅H₂₈N₆O₃
Molecular Weight	460.528
Flash Point	366.3±34.3 °C
Exact Mass	460.222290
LogP	1.76
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.680
Storage condition	2-8°C

1-({(5S,7S)-3-[5-(2-Hydroxy-2-propanyl)-2-pyrazinyl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]dec-7-yl}methyl)-1H-benzimidazole-6-carbonitrile

1H-Benzimidazole-6-carbonitrile, 1-[[(5S,7S)-3-[5-(1-hydroxy-1-methylethyl)-2-pyrazinyl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]dec-7-yl]methyl]-

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: GSK2798745
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: GSK2798745
Price: ￥700.0/10mg
Purity: 98.0%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: GSK2798745
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.