Brexpiprazole D8

Modify Date: 2024-01-09 10:18:10

Brexpiprazole D8 structure	Common Name	Brexpiprazole D8
	CAS Number	1427049-21-5	Molecular Weight	441.615
	Density	1.2±0.1 g/cm3	Boiling Point	675.2±55.0 °C at 760 mmHg
	Molecular Formula	C₂₅H₁₉D₈N₃O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	362.1±31.5 °C

Use of Brexpiprazole D8

Brexpiprazole D8 (OPC-34712 D8) is a deuterium labeled Brexpiprazole (OPC-34712). Brexpiprazole, an atypical antipsychotic drug, is a partial agonist of human 5-HT1A and dopamine receptor (Ki=0.12 nM and 0.3 nM, respectively). Brexpiprazole is also a 5-HT2A receptor antagonist (Ki=0.47 nM)[1][2].

Name	Brexpiprazole-d8
Synonym	More Synonyms

Description	Brexpiprazole D8 (OPC-34712 D8) is a deuterium labeled Brexpiprazole (OPC-34712). Brexpiprazole, an atypical antipsychotic drug, is a partial agonist of human 5-HT1A and dopamine receptor (Ki=0.12 nM and 0.3 nM, respectively). Brexpiprazole is also a 5-HT2A receptor antagonist (Ki=0.47 nM)[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
References	[1]. Ishima T, et al. Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-HT1A and 5-HT2A receptors. Eur Neuropsychopharmacol. 2015 Apr;25(4):505-11. [2]. Yoshimi N, et al. Improvement of dizocilpine-induced social recognition deficits in mice by brexpiprazole, a novel serotonin-dopamine activity modulator. Eur Neuropsychopharmacol. 2015 Mar;25(3):356-64.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

References

[1]. Ishima T, et al. Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-HT1A and 5-HT2A receptors. Eur Neuropsychopharmacol. 2015 Apr;25(4):505-11.

[2]. Yoshimi N, et al. Improvement of dizocilpine-induced social recognition deficits in mice by brexpiprazole, a novel serotonin-dopamine activity modulator. Eur Neuropsychopharmacol. 2015 Mar;25(3):356-64.

Density	1.2±0.1 g/cm3
Boiling Point	675.2±55.0 °C at 760 mmHg
Molecular Formula	C₂₅H₁₉D₈N₃O₂S
Molecular Weight	441.615
Flash Point	362.1±31.5 °C
Exact Mass	441.232605
LogP	5.82
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.646

7-{4-[4-(1-Benzothiophen-4-yl)(2H8)-1-piperazinyl]butoxy}-2(1H)-quinolinone

2(1H)-Quinolinone, 7-[4-(4-benzo[b]thien-4-yl-1-piperazinyl-2,2,3,3,5,5,6,6-d8)butoxy]-

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Brexpiprazole-d8
Price: Negotiable
Purity: 98.0%
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