ML216
Modify Date: 2025-09-02 14:43:39
ML216 structure
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Common Name | ML216 | ||
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| CAS Number | 1430213-30-1 | Molecular Weight | 383.323 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C15H9F4N5OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ML216ML216(CID-49852229) is a potent inhibitor of the DNA unwinding activity of BLM helicase; showing similar IC50s of 3.0 and 0.97 μM for full length BLM and BLM636–1298 respectively.IC50 value: 3.0/0.97 uM(Full length/636–1298 BLM)Target: BLM helicase inhibitorML216 shows cell-based activity, and can induce sister chromatid exchanges, enhance to the toxicity of aphidicolin and exert anti-proliferative activity in cells expressing BLM, but not in those lacking BLM. |
| Name | 1-[4-Fluoro-3-(trifluoromethyl)phenyl]-3-[5-(4-pyridinyl)-1,3,4-t hiadiazol-2-yl]ure |
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| Synonym | More Synonyms |
| Description | ML216(CID-49852229) is a potent inhibitor of the DNA unwinding activity of BLM helicase; showing similar IC50s of 3.0 and 0.97 μM for full length BLM and BLM636–1298 respectively.IC50 value: 3.0/0.97 uM(Full length/636–1298 BLM)Target: BLM helicase inhibitorML216 shows cell-based activity, and can induce sister chromatid exchanges, enhance to the toxicity of aphidicolin and exert anti-proliferative activity in cells expressing BLM, but not in those lacking BLM. |
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| Related Catalog | |
| References |
| Density | 1.6±0.1 g/cm3 |
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| Molecular Formula | C15H9F4N5OS |
| Molecular Weight | 383.323 |
| Exact Mass | 383.046387 |
| PSA | 114.76000 |
| LogP | 4.11 |
| Index of Refraction | 1.641 |
| Storage condition | 2-8℃ |
| Urea, N-[4-fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]- |
| 1-[4-Fluoro-3-(trifluoromethyl)phenyl]-3-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]urea |
| ML216 |