DBCO-S-S-PEG3-Biotin

Modify Date: 2024-01-22 22:43:32

DBCO-S-S-PEG3-Biotin Structure
DBCO-S-S-PEG3-Biotin structure
Common Name DBCO-S-S-PEG3-Biotin
CAS Number 1430408-09-5 Molecular Weight 869.124
Density 1.3±0.1 g/cm3 Boiling Point 1194.2±65.0 °C at 760 mmHg
Molecular Formula C42H56N6O8S3 Melting Point N/A
MSDS N/A Flash Point 676.0±34.3 °C

 Use of DBCO-S-S-PEG3-Biotin


DBCO-S-S-PEG3-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name N-[24-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-13,21,24-trioxo-3,6,9-trioxa-16,17-dithia-12,20-diazatetracos-1-yl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
Synonym More Synonyms

 DBCO-S-S-PEG3-Biotin Biological Activity

Description DBCO-S-S-PEG3-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 1194.2±65.0 °C at 760 mmHg
Molecular Formula C42H56N6O8S3
Molecular Weight 869.124
Flash Point 676.0±34.3 °C
Exact Mass 868.332153
LogP 3.12
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.641
Storage condition -20°C

 Synonyms

N-[24-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-13,21,24-trioxo-3,6,9-trioxa-16,17-dithia-12,20-diazatetracos-1-yl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
Dibenz[b,f]azocine-5(6H)-butanamide, 11,12-didehydro-N-[25-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-7,21-dioxo-11,14,17-trioxa-3,4-dithia-8,20-diazapentacos-1-yl]-γ-oxo-
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