Zidebactam

Modify Date: 2024-01-04 18:49:20

Zidebactam Structure
Zidebactam structure
Common Name Zidebactam
CAS Number 1436861-97-0 Molecular Weight 391.40
Density 1.6±0.1 g/cm3 Boiling Point N/A
Molecular Formula C13H21N5O7S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Zidebactam


Zidebactam (WCK-5107) is a potent β-lactamase inhibitor[1]. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC50 of 0.26 μg/mL[2].

 Names

Name zidebactam
Synonym More Synonyms

 Zidebactam Biological Activity

Description Zidebactam (WCK-5107) is a potent β-lactamase inhibitor[1]. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC50 of 0.26 μg/mL[2].
Related Catalog
Target

IC50: 0.26 μg/mL (P. aeruginosa PAO1 PBP2)[2]

In Vitro Zidebactam (WCK-5107) inhibits WT Enterobacteriaceae with a MIC50 of 0.25 mg/L. Zidebactam alone exhibits variable activity when tested against E. coli (MIC50/90 0.12/0.12  mg/L) and Enterobacter spp. (MIC50/90 0.12/0.25  mg/L)[1].
References

[1]. Sader HS, et al. WCK 5222 (cefepime/zidebactam) antimicrobial activity tested against Gram-negative organisms producing clinically relevant β-lactamases. J Antimicrob Chemother. 2017 Jun 1;72(6):1696-1703.

[2]. Moya B, et al. WCK 5107 (Zidebactam) and WCK 5153 Are Novel Inhibitors of PBP2 Showing Potent "β-Lactam Enhancer" Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-β-Lactamase-Producing High-Risk Clones. Antimicrob Agents Chemother. 2017 May 24;61(6).

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Molecular Formula C13H21N5O7S
Molecular Weight 391.40
Exact Mass 391.116180
LogP -3.01
Index of Refraction 1.653
Storage condition 2-8℃

 Synonyms

zidebactam
1,6-Diazabicyclo[3.2.1]octane-2-carboxylic acid, 7-oxo-6-(sulfooxy)-, 2-[2-[(3R)-3-piperidinylcarbonyl]hydrazide], (2S,5R)-
YPM97423DB
(2S,5R)-7-Oxo-N'-[(3R)-3-piperidinylcarbonyl]-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carbohydrazide
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