Larotinib

Modify Date: 2024-01-22 15:38:24

Larotinib structure	Common Name	Larotinib
	CAS Number	1438072-11-7	Molecular Weight	488.94
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₆ClFN₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Larotinib

Larotinib is a potent broad-spectrum and orally active tyrosine kinase inhibitor (TKI) with EGFR as the main target with an IC50 of 0.6 nM[1].

Name	Larotinib

Description	Larotinib is a potent broad-spectrum and orally active tyrosine kinase inhibitor (TKI) with EGFR as the main target with an IC50 of 0.6 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Immunology/Inflammation >> IRAK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK
Target	EGFRL861Q:0.423 nM (IC50) EGFRL858R:0.563 nM (IC50) EGFR (WT):0.611 nM (IC50) EGFRT790M:45.2 nM (IC50) HER4:84 nM (IC50) BLK:102 nM (IC50) IRAK1:167 nM (IC50) BTK:196 nM (IC50) HER2:253 nM (IC50)
In Vivo	每日给 Larotinib mesylate 后，SD 大鼠无不良反应水平 (NOAEL) 为 10 mg/kg, 比格犬最低不良反应水平 (LOAEL) 为 5 mg/kg。最大耐受剂量 (MTDs) 在 SD 大鼠和比格犬中分别为 20 和 25 mg/kg[1]。 Larotinib mesylate 显示出剂量依赖性的抗肿瘤结果，在肿瘤小鼠模型中，18 mg/kg 肿瘤抑制率超过 60% (数据未发表)[1]。
References	[1]. Liu J, et al. Phase I Trial to Evaluate the Tolerance, Pharmacokinetics and Efficacy of the Broad-Spectrum ErbB Family Inhibitor Larotinib Mesylate in Patients With Advanced Solid Tumors. Front Pharmacol. 2021 Feb 18;12:636324.

Molecular Formula	C₂₄H₂₆ClFN₄O₄
Molecular Weight	488.94

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Larotinib
Price: Check
Purity: 98.45%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Get all suppliers and price by the below link:

Larotinib suppliers

Larotinib price