Trihexylphenedyl

Modify Date: 2025-08-21 14:26:34

Trihexylphenedyl structure	Common Name	Trihexylphenedyl
	CAS Number	144-11-6	Molecular Weight	301.46600
	Density	1.04g/cm3	Boiling Point	447.9ºC at 760 mmHg
	Molecular Formula	C₂₀H₃₁NO	Melting Point	258.5ºC
	MSDS	N/A	Flash Point	211ºC

Use of Trihexylphenedyl

Trihexyphenidyl is a potent and selective M1 muscarinic receptor antagonist. Trihexyphenidyl shows anticholinergic activity, and can be used for Parkinson syndrome or dystonia research[1][2].

Name	1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol
Synonym	More Synonyms

Description	Trihexyphenidyl is a potent and selective M1 muscarinic receptor antagonist. Trihexyphenidyl shows anticholinergic activity, and can be used for Parkinson syndrome or dystonia research[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
References	[1]. Giachetti A, et al. Binding and functional profiles of the selective M1 muscarinic receptor antagonists trihexyphenidyl and dicyclomine. Br J Pharmacol. 1986 Sep;89(1):83-90. [2]. Jilani TN, et al. Trihexyphenidyl. 2022 Feb 27. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–.

Description

Trihexyphenidyl is a potent and selective M1 muscarinic receptor antagonist. Trihexyphenidyl shows anticholinergic activity, and can be used for Parkinson syndrome or dystonia research[1][2].

Related Catalog

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

References

[1]. Giachetti A, et al. Binding and functional profiles of the selective M1 muscarinic receptor antagonists trihexyphenidyl and dicyclomine. Br J Pharmacol. 1986 Sep;89(1):83-90.

[2]. Jilani TN, et al. Trihexyphenidyl. 2022 Feb 27. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–.

Density	1.04g/cm3
Boiling Point	447.9ºC at 760 mmHg
Melting Point	258.5ºC
Molecular Formula	C₂₀H₃₁NO
Molecular Weight	301.46600
Flash Point	211ºC
Exact Mass	301.24100
PSA	23.47000
LogP	4.26840
Vapour Pressure	8.34E-09mmHg at 25°C
Index of Refraction	1.546

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TN2620000

CHEMICAL NAME :: 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-

CAS REGISTRY NUMBER :: 144-11-6

BEILSTEIN REFERENCE NO. :: 0088959

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H31-N-O

MOLECULAR WEIGHT :: 301.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 335 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1778,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - excitement Behavioral - irritability

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1727,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 153 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 23,8,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 41 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 226,18,1955

HS Code	2933399090

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Trihexylphenedyl

CAS#:144-11-6

Literature: Journal of the Chemical Society, , p. 52,58 Journal of the American Chemical Society, , vol. 71, p. 2050,2052 Journal of the American Chemical Society, , vol. 72, p. 3795 Journal of the American Chemical Society, , vol. 72, p. 718,719 US2717121 , ;

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Literature: Archiv der Pharmazie (Weinheim, Germany), , vol. 291, p. 36,42

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Literature: Journal of the Chemical Society, , p. 52,58

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Trihexylphenedyl

CAS#:144-11-6

Literature: Archiv der Pharmazie (Weinheim, Germany), , vol. 291, p. 36,42

Precursor 8
CAS#:73-63-2 β-Piperidinopro... CAS#:931-50-0 CYCLOHEXYLMAGNE... CAS#:110-89-4 Piperidine CAS#:13487-73-5 3-chloro-1-cycl...
CAS#:511-45-5 pridinol CAS#:108-85-0 Bromocyclohexane CAS#:108-86-1 Bromobenzene CAS#:19653-33-9 1-Piperidinepro...
DownStream 0

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Parkinane retard

Trihexane

trihexyphenidyle

Artane

1-cyclohexyl-1-phenyl-3-piperidin-1-yl-propan-1-ol

trihexyphenidyl

Benzhexolum

Trihexifenidilo

EINECS 205-614-4

Cyclodol

Benzhexol

Triphenidyl

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