Chloroquinine phosphate

MOLECULAR WEIGHT :

417.92

WISWESSER LINE NOTATION :

T66 BNJ EMY1&3N2&2 IG &P-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human

DOSE/DURATION :

43 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :

JFSCAS Journal of Forensic Sciences. (American Soc. for Testing and Materials, 1916 Race St., Philadelphia, PA 19103) V.1- 1956- Volume(issue)/page/year: 5,201,1965

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

2740 mg/kg/39W

TOXIC EFFECTS :

Behavioral - muscle weakness

REFERENCE :

ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS. Volume(issue)/page/year: 93,209,1972

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - child

DOSE/DURATION :

38 mg/kg

TOXIC EFFECTS :

Cardiac - other changes Lungs, Thorax, or Respiration - other changes

REFERENCE :

PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034, Evanston, IL 60204) V.1- 1948- Volume(issue)/page/year: 27,95,1961 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

2660 mg/kg

SEX/DURATION :

female 2-39 week(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Effects on Newborn - other neonatal measures or effects Reproductive - Effects on Newborn - other postnatal measures or effects

REFERENCE :

AROTAA Archives of Otolaryngology. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-52, 1925-50; V.72- 1960- Volume(issue)/page/year: 80,407,1964

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

455 mg/kg

SEX/DURATION :

female 1-13 week(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - abortion

REFERENCE :

AROTAA Archives of Otolaryngology. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-52, 1925-50; V.72- 1960- Volume(issue)/page/year: 80,407,1964

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

420 mg/kg

SEX/DURATION :

female 1-6 week(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :

AROTAA Archives of Otolaryngology. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-52, 1925-50; V.72- 1960- Volume(issue)/page/year: 80,407,1964

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intramuscular

DOSE :

25 mg/kg

SEX/DURATION :

female 18 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - abortion

REFERENCE :

CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 31,173,1985