Lifirafenib
Modify Date: 2025-09-18 14:02:27
Lifirafenib structure
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Common Name | Lifirafenib | ||
|---|---|---|---|---|
| CAS Number | 1446090-79-4 | Molecular Weight | 478.42300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H17F3N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of LifirafenibLifirafenib (BGB-283) potently inhibits RAF family kinases and EGFR activities in biochemical assays with IC50 values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant. |
| Name | 5-(((1R,1aS,6bR)-1-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one |
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| Synonym | More Synonyms |
| Molecular Formula | C25H17F3N4O3 |
|---|---|
| Molecular Weight | 478.42300 |
| Exact Mass | 478.12500 |
| PSA | 89.13000 |
| LogP | 5.43370 |
| InChIKey | NGFFVZQXSRKHBM-FKBYEOEOSA-N |
| SMILES | O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4ccc(C(F)(F)F)cc4[nH]3)ccnc2N1 |
| Storage condition | -20℃ |
| Lifirafenib |