4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile

Modify Date: 2024-01-04 16:50:03

4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile Structure
4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile structure
Common Name 4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile
CAS Number 144702-27-2 Molecular Weight 495.61700
Density 1.188g/cm3 Boiling Point 775.126ºC at 760 mmHg
Molecular Formula C33H29N5 Melting Point 181.2-182.1 ºC
MSDS N/A Flash Point 422.581ºC

 Names

Name 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzonitrile
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.188g/cm3
Boiling Point 775.126ºC at 760 mmHg
Melting Point 181.2-182.1 ºC
Molecular Formula C33H29N5
Molecular Weight 495.61700
Flash Point 422.581ºC
Exact Mass 495.24200
PSA 59.43000
LogP 7.43788
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.664
Water Solubility Insuluble (5.0E-6 g/L) (25 ºC)

 Synthetic Route

~89%

4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile Structure

4'-[(1,4'-Dimet...

CAS#:144702-27-2

Literature: Boehringer Ingelheim International GmbH Patent: US2004/236113 A1, 2004 ; Location in patent: Page 4 ;

~%

4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile Structure

4'-[(1,4'-Dimet...

CAS#:144702-27-2

Literature: U AMARNATH, Amarnath; U SURYAKIRAN, Suryakiran Patent: WO2014/27280 A1, 2014 ; Location in patent: Page/Page column 6-7 ;

~87%

4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile Structure

4'-[(1,4'-Dimet...

CAS#:144702-27-2

Literature: KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO Patent: WO2009/4064 A1, 2009 ; Location in patent: Page/Page column 39-40 ;

~87%

4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile Structure

4'-[(1,4'-Dimet...

CAS#:144702-27-2

Literature: KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO Patent: WO2009/4064 A1, 2009 ; Location in patent: Page/Page column 42 ;

~%

4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile Structure

4'-[(1,4'-Dimet...

CAS#:144702-27-2

Literature: WO2010/146187 A2, ; Page/Page column 40-41 ;

~45%

4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile Structure

4'-[(1,4'-Dimet...

CAS#:144702-27-2

Literature: KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO Patent: WO2009/4064 A1, 2009 ; Location in patent: Page/Page column 44 ;

~%

4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile Structure

4'-[(1,4'-Dimet...

CAS#:144702-27-2

Literature: WO2014/27280 A1, ;

 Synonyms

BIP007
2-Descarboxy-2-cyano Telmisartan
Telmisartan Impurity G
UNII-A8M0GXG1XV
(1,1'-Biphenyl)-2-carbonitrile,4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)
4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl
4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl
4'-{[2-n-propyl-4-methyl-6-(1-methylbenzoimidazol-2-yl)benzoimidazol-1-yl]methyl}-2-cyanobiphenyl
Telmisartan impurity G [EP]
2-cyano-4'-[2''-n-propyl-4''-methyl-6''-(1'''-methylbenzimidazole-2'''-yl)benzimidazole-1''-ylmethyl]biphenyl
2-cyano-4'-(2''-n-propyl-4''-methyl-6''-(1'''-methylbenzimidazol-2'''-yl)benzimidazol-1''-ylmethyl)biphenyl
4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile
Telmisartan Impurity 7