A 77636 hydrochloride
Modify Date: 2025-08-26 22:35:52
A 77636 hydrochloride structure
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Common Name | A 77636 hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 145307-34-2 | Molecular Weight | 365.89400 | |
| Density | N/A | Boiling Point | 515.3ºC at 760 mmHg | |
| Molecular Formula | C20H28ClNO3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 265.5ºC | |
Use of A 77636 hydrochlorideA-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor[1][2]. |
| Name | (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | A-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor[1][2]. |
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| Related Catalog | |
| In Vivo | A-77636 (0.1-1 mg/kg) exerts a suppressant effect on food intake, due principally to a reduction in meal size and duration[3]. Animal Model: Male hooded rat[1] Dosage: 0.1, 0.3 and 1.0 mg/kg Administration: S.c. Result: Exerted a suppressant effect on food intake, due principally to a reduction in meal size and duration. |
| References |
| Boiling Point | 515.3ºC at 760 mmHg |
|---|---|
| Molecular Formula | C20H28ClNO3 |
| Molecular Weight | 365.89400 |
| Flash Point | 265.5ºC |
| Exact Mass | 365.17600 |
| PSA | 75.71000 |
| LogP | 4.75760 |
| Vapour Pressure | 3.06E-11mmHg at 25°C |
| InChIKey | BWHPNJVKFAPVOG-QYFJGNGUSA-N |
| SMILES | Cl.NCC1OC(C23CC4CC(CC(C4)C2)C3)Cc2c1ccc(O)c2O |
| Storage condition | -20°C |
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~81%
A 77636 hydroch... CAS#:145307-34-2 |
| Literature: DeNinno; Perner; Morton; DiDomenico Jr. Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7115 - 7118 |
|
~%
A 77636 hydroch... CAS#:145307-34-2 |
| Literature: DeNinno; Perner; Morton; DiDomenico Jr. Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7115 - 7118 |
|
~%
A 77636 hydroch... CAS#:145307-34-2 |
| Literature: DeNinno; Perner; Morton; DiDomenico Jr. Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7115 - 7118 |
|
~%
A 77636 hydroch... CAS#:145307-34-2 |
| Literature: DeNinno; Perner; Morton; DiDomenico Jr. Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7115 - 7118 |
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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|
Name: Thermal Shift Assay. Domain: start/stop: M1-L298
Source: ChEMBL
Target: Cyclin-dependent kinase 2
External Id: CHEMBL5062802
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Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
Source: 23265
External Id: IucA Pilot Assay Tocris Library
|
|
Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
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|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
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|
Name: Thermal Shift Assay. Domain: start/stop: M26-R383
Source: ChEMBL
Target: Glycogen synthase kinase-3 beta
External Id: CHEMBL5065843
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|
Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
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Name: PDSP Secondary Binding target: ADRA2B - Compounds are tested at 10 uM concentration, ...
Source: ChEMBL
Target: Alpha-2B adrenergic receptor
External Id: CHEMBL5442195
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| A-77636 hydrochloride hydrate |
| (1R,3S)-3-(1'-adamantyl)-1-aminomethyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride |