Pocapavir

Modify Date: 2024-01-06 19:00:57

Pocapavir Structure
Pocapavir structure
Common Name Pocapavir
CAS Number 146949-21-5 Molecular Weight 423.717
Density 1.3±0.1 g/cm3 Boiling Point 541.4±45.0 °C at 760 mmHg
Molecular Formula C21H17Cl3O3 Melting Point N/A
MSDS N/A Flash Point 176.5±28.8 °C

 Use of Pocapavir


Pocapavir is an investigational enterovirus (EV) capsid inhibitor.

 Names

Name Pocapavir
Synonym More Synonyms

 Pocapavir Biological Activity

Description Pocapavir is an investigational enterovirus (EV) capsid inhibitor.
Related Catalog
In Vitro Pocapavir acts as a capsid inhibitor, preventing virion uncoating upon entry into the cell. Treatment with Pocapavir is safe and significantly accelerates virus clearance[1]. Pocapavir, an investigational oral antiviral, has been used in a case of neonatal enterovirus sepsis. Pocapavir, also known as SCH 48973 and V-073, is a potent, selective anti-enteroviral agent only available as an emergency investigational drug. Pocapavir belongs to a picornavirus antiviral mechanistic class called capsid inhibitors that block virus uncoating and viral RNA release into cells, which in turn prevents virus replication[2].
References

[1]. Collett MS, et al. Antiviral Activity of Pocapavir in a Randomized, Blinded, Placebo-Controlled Human Oral Poliovirus Vaccine Challenge Model. J Infect Dis. 2017 Feb 1;215(3):335-343.

[2]. Wittekind SG, et al. Neonatal Enterovirus Myocarditis With Severe Dystrophic Calcification: Novel Treatment WithPocapavir. J Investig Med High Impact Case Rep. 2017 Sep 14;5(3):2324709617729393.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 541.4±45.0 °C at 760 mmHg
Molecular Formula C21H17Cl3O3
Molecular Weight 423.717
Flash Point 176.5±28.8 °C
Exact Mass 422.024323
LogP 7.20
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.606
Storage condition 2-8℃

 Synonyms

9602
Benzene, 1-((2-chloro-4-methoxyphenoxy)methyl)-4-((2,6-dichlorophenoxy)methyl)-
4ILA3VOV97
Benzene, 1-[(2-chloro-4-methoxyphenoxy)methyl]-4-[(2,6-dichlorophenoxy)methyl]-
Pocapavir
1,3-Dichloro-2-({4-[(2-chloro-4-methoxyphenoxy)methyl]benzyl}oxy)benzene
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