Cefcapene pivoxil hydrochloride

Modify Date: 2025-09-18 21:31:27

Cefcapene pivoxil hydrochloride Structure
Cefcapene pivoxil hydrochloride structure
Common Name Cefcapene pivoxil hydrochloride
CAS Number 147816-23-7 Molecular Weight 604.09600
Density N/A Boiling Point N/A
Molecular Formula C23H30ClN5O8S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Cefcapene pivoxil hydrochloride


Cefcapene pivoxil hydrochloride, an antibiotic, is an orally active and potent 3rd-generation cephalosporin with a wide spectrum of anti-bacterial activity[1].Cefcapene pivoxil hydrochloride has the potential for the palmoplantar pustulosis (PPP) treatment[2].

 Names

Name 2,2-dimethylpropanoyloxymethyl (6R,7R)-7-[[(Z)-2-(2-amino-1,3-thiazol-4-yl)pent-2-enoyl]amino]-3-(carbamoyloxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate,hydrochloride
Synonym More Synonyms

 Cefcapene pivoxil hydrochloride Biological Activity

Description Cefcapene pivoxil hydrochloride, an antibiotic, is an orally active and potent 3rd-generation cephalosporin with a wide spectrum of anti-bacterial activity[1].Cefcapene pivoxil hydrochloride has the potential for the palmoplantar pustulosis (PPP) treatment[2].
Related Catalog
Target

IC50: bacterial[1]

In Vivo Cefcapene pivoxil hydrochloride (oral administration; 100mg/kg; 4 days) is effective against invasive BLNAR strains in mice lung, stimates peak antibiotic concentrations of 1 to 2 μg/ml in the blood of mice from 30 to 120 min after intragastric administration[3]. Animal Model: Four-week-old female C57BL/6J mice with bacterial suspension in BSG (1×109 CFU)[3] Dosage: 100 mg/kg Administration: Oral administration; 100mg/kg; 4 days Result: Was against H. influenzae colonization in mouse lung.
References

[1]. Murakami M, et al. Cefcapene Pivoxil Hydrochloride Is a Potentially New Treatment for Palmoplantar Pustulosis with Pustulotic Arthro-Osteitis.Dermatology. 2015;231(4):304-11.

[2]. 3.Kawada A, et al. Drug eruption induced by cefcapene pivoxil hydrochloride.Contact Dermatitis. 2001 Mar;44(3):197.

[3]. Sekiya Y, et al. Comparative efficacies of different antibiotic treatments to eradicate nontypeable Haemophilus influenzae infection.BMC Infect Dis. 2008 Feb 7;8:15.

 Chemical & Physical Properties

Molecular Formula C23H30ClN5O8S2
Molecular Weight 604.09600
Exact Mass 603.12200
PSA 251.99000
LogP 3.38210

 Synonyms

Cefcapene pivoxil
Flomox
Flumax
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