jmv 390-1

Modify Date: 2024-01-11 16:44:29

jmv 390-1 Structure
jmv 390-1 structure
Common Name jmv 390-1
CAS Number 148473-36-3 Molecular Weight 449.54
Density 1.177g/cm3 Boiling Point N/A
Molecular Formula C23H35N3O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of jmv 390-1


JMV 390-1 (Compound 6a) is a potent multipeptidase inhibitor. JMV 390-1 behaves as a full inhibitor of the major neurotensin (NT)/neuromedin N (NN) degrading enzymes in vitro with IC50 values from 30 to 60 nM. JMV 390-1 increases endogenous recovery of NT and NN from slices of mice hypothalamus depolarized with potassium[1].

 Names

Name jmv 390-1
Synonym More Synonyms

 jmv 390-1 Biological Activity

Description JMV 390-1 (Compound 6a) is a potent multipeptidase inhibitor. JMV 390-1 behaves as a full inhibitor of the major neurotensin (NT)/neuromedin N (NN) degrading enzymes in vitro with IC50 values from 30 to 60 nM. JMV 390-1 increases endogenous recovery of NT and NN from slices of mice hypothalamus depolarized with potassium[1].
Related Catalog
References

[1]. Doulut S, et al. Synthesis and analgesic effects of N-[3-[(hydroxyamino) carbonyl]-1-oxo-2(R)-benzylpropyl]-L-isoleucyl-L-leucine, a new potent inhibitor of multiple neurotensin/neuromedin N degrading enzymes. J Med Chem. 1993 May 14;36(10):1369-79.

 Chemical & Physical Properties

Density 1.177g/cm3
Molecular Formula C23H35N3O6
Molecular Weight 449.54
Exact Mass 449.25300
PSA 155.30000
LogP 4.40810
Index of Refraction 1.536

 Synonyms

(2S)-2-[[(2S,3S)-2-[[(2R)-2-benzyl-4-(hydroxyamino)-4-oxobutanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid
Jmv 390-1