Amyloid β-Protein (31-35)

Modify Date: 2024-01-10 08:08:08

Amyloid β-Protein (31-35) Structure
Amyloid β-Protein (31-35) structure
Common Name Amyloid β-Protein (31-35)
CAS Number 149385-65-9 Molecular Weight 545.73600
Density 1.137 g/cm3 Boiling Point 866.382ºC at 760 mmHg
Molecular Formula C25H47N5O6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Amyloid β-Protein (31-35)


β-Amyloid (31-35) is the shortest sequence of native Amyloid-β peptide that retains neurotoxic activity.

 Names

Name h-ile-ile-gly-leu-met-oh
Synonym More Synonyms

 Amyloid β-Protein (31-35) Biological Activity

Description β-Amyloid (31-35) is the shortest sequence of native Amyloid-β peptide that retains neurotoxic activity.
Related Catalog
In Vitro β-Amyloid (31-35) is a functional cytotoxic domain of Aβ peptide. β-Amyloid (31-35) increases the phosphorylation of biotinylated Aβ(1-40), enhances CDK-1 activity, and also inhibits binding of Aβ to cyclin B1. β-Amyloid (31-35) is cytotoxic, and such an effect can be inhibited by olomoucine in differentiated human teratocarcinoma cell line, Ntera 2/cl-D1 (NT-2) neurons[1]. β-Amyloid (31-35) shows cytotoxic effect on cerebellar granule cells (CGC). β-Amyloid (31-35) also increases caspase-3 activity in a time-dependent manner (4-24 h) at 40 μM[2].
References

[1]. Milton NG, et al. The amyloid-beta peptide binds to cyclin B1 and increases human cyclin-dependent kinase-1 activity. Neurosci Lett. 2002 Apr 5;322(2):131-3.

[2]. Misiti F, et al. Fragment 31-35 of beta-amyloid peptide induces neurodegeneration in rat cerebellar granule cells via bax gene expression and caspase-3 activation. A crucial role for the redox state of methionine-35 residue. Neurochem Int. 2006 Oct;49(5):525-32.

 Chemical & Physical Properties

Density 1.137 g/cm3
Boiling Point 866.382ºC at 760 mmHg
Molecular Formula C25H47N5O6S
Molecular Weight 545.73600
Exact Mass 545.32500
PSA 205.02000
LogP 3.12420
Storage condition −20°C

 Synonyms

IIGLM
Isoleucinyl-isoleucinyl-glycinyl-leucinyl-methionine
amyloid B-protein fragment 31-35*acetate
ILE-ILE-GLY-LEU-MET
Amyloid β-Protein (31-35)
β-Amyloid (31-35)
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