Tri-n-propylphosphine oxide

Synonym:Tri-n-propylphosphine oxide

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Section 2: Composition and Information on Ingredients
IngredientCAS NumberPercentACGIH (TWA)OSHA (PEL)
Title Compound1496-94-2100%no datano data

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Section 3: Hazards Identification
Harmful in contact with skin and if swallowed. The material is irritating to skin, eyes, and mucous membranes.
Emergency Overview:
Primary Routes of Exposure:Ingestion, eyes, inhalation
Eye Contact:Causes moderate irritation of the eyes
Skin Contact:Causes moderate irritation of the skin. Harmful in contact with skin.
Inhalation:The dust is irritating to the nose, mucous membranes and respiratory tract.
Ingestion:Harmful if swallowed. May cause vomiting and diarrhea.
Acute Health Affects:Harmful in contact with skin and if swallowed. Irritating to skin, eyes and respiratory tract.
Chronic Health Affects:No information available on long-term chronic effects.
NTP:No
IARC:No
OSHA:No

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SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.

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SECTION 5: Fire Fighting Measures
Flash Point:not applicable
Autoignition Temperature:no data
Explosion Limits:no data
Extinguishing Medium:carbon dioxide, dry powder or foam
If involved in a fire, fire fighters should be equipped with a NIOSH approved positive pressure self-contained
Special Fire Fighting Procedures:
breathing apparatus and full protective clothing.
Hazardous Combustion andIn a fire may emit toxic organic fumes, carbon monoxide, carbon dioxide, and phosphorous pentoxide.
Decomposion Products:
Unusual Fire or Explosion Hazards: No unusual fire or explosion hazards.

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SECTION 6: Accidental Release Measures
Spill and Leak Procedures:Small spills can be mixed with vermiculite or sodium carbonate and swept up.

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SECTION 7: Handling and Storage
Handling and Storage:Store in a tightly sealed container. Keep away from heat and direct sunlight.

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SECTION 8: Exposure Controls and Personal Protection
Eye Protection:Always wear approved safety glasses when handling a chemical substance in the laboratory.
Skin Protection:Wear protective clothing and gloves. Consult with glove manufacturer to determine the proper type of glove.
Ventilation:Material may form a fine dust. If possible, handle the material in an efficient fume hood.
If ventilation is not available a respirator should be worn. The use of respirators requires a Respirator
Respirator:
Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation:Material may form a fine dust. If possible, handle the material in an efficient fume hood.
Additional Protection:No additional protection required.

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SECTION 9: Physical and Chemical Properties
Color and Form:white xtl.
Molecular Weight:176.24
Melting Point:39°
Boiling Point:280-282°C
Vapor Pressure:no data
Specific Gravity:no data
Odor:sweetish odor
Solubility in Water:slightly soluble

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SECTION 10: Stability and Reactivity
Stability:moisture sensitive
Hazardous Polymerization:no hazardous polymerization
Conditions to Avoid:contact with strong oxidizing agents
Incompatibility:oxidizing agents and halogens
Decomposition Products:carbon dioxide, carbon monoxide, organic fumes, and phosphorus oxides.

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SECTION 11: Toxicological Information
Administration onto the skin (rabbit); Standard Draize test: 10 uL/24H. Adminstration into the eye (rabbit);
RTECS Data:Standard Draize test: 5 uL. Oral (rat); LD50: 1410 mg/kg. Oral (mouse) LD50: 1360 mg/kg. Administration onto
the skin (rabbit); LD50: 1130 mg/kg. Oral (rat); TDLo: 9300 mg/kg/30D-I.
Carcinogenic Effects:No data available
Mutagenic Effects:No data available
Tetratogenic Effects:No data available

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SECTION 12: Ecological Information
Ecological Information:No information available

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SECTION 13: Disposal Considerations
Disposal:Dispose of according to federal, state, and local regulations.

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SECTION 14: Transportation
Shipping Name (CFR):Non-hazardous
Hazard Class (CFR):NA
Additional Hazard Class (CFR):NA
Packaging Group (CFR):NA
UN ID Number (CFR):NA
Shipping Name (IATA):Non-hazardous
Hazard Class (IATA):NA
Additional Hazard Class (IATA):NA
Packaging Group (IATA):NA
UN ID Number (IATA):NA

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SECTION 15: Regulatory Information
TSCA:Listed in the TSCA inventory.
SARA (Title 313):Title compound not listed.
Second Ingredient:none

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SECTION 16 - ADDITIONAL INFORMATION
N/A

MOLECULAR FORMULA :

C9-H21-O-P

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1550 mg/kg

TOXIC EFFECTS :

Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(2),92,1984

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1360 mg/kg

TOXIC EFFECTS :

Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(2),92,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

9300 mg/kg/30D-I

TOXIC EFFECTS :

Liver - liver function tests impaired Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(2),92,1984