Uprifosbuvir

Modify Date: 2025-08-25 20:51:27

Uprifosbuvir structure	Common Name	Uprifosbuvir
	CAS Number	1496551-77-9	Molecular Weight	545.907
	Density	1.4±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₉ClN₃O₉P	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Uprifosbuvir

Uprifosbuvir is an antiviral agent. Uprifosbuvir is a NS5b inhibitor developed for the research of chronic hepatitis C virus[1].

Name	Uprifosbuvir
Synonym	More Synonyms

Description	Uprifosbuvir is an antiviral agent. Uprifosbuvir is a NS5b inhibitor developed for the research of chronic hepatitis C virus[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection
References	[1]. Klapars A, et al. Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methods. Chem Sci. 2021;12(26):9031-9036.

Density	1.4±0.1 g/cm3
Molecular Formula	C₂₂H₂₉ClN₃O₉P
Molecular Weight	545.907
Exact Mass	545.132996
LogP	1.45
Index of Refraction	1.588
InChIKey	SFPFZQKYPOWCSI-KHFYHRBSSA-N
SMILES	CC(C)OC(=O)C(C)NP(=O)(OCC1OC(n2ccc(=O)[nH]c2=O)C(C)(Cl)C1O)Oc1ccccc1
Storage condition	2-8°C

Name: AUC (0 to t) in human cardiomyocytes assessed as ((2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4046691

Name: Drug metabolism assessed as CYP3A4 (unknown origin)-mediated (R)-2-((R)-(((2R,3R,4R,5...
Source: ChEMBL
Target: Cytochrome P450 3A4
External Id: CHEMBL4046692

Name: AUC (0 to t) in human hepatocytes assessed as ((2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4046690

Name: AUC (0 to t) in human Huh-7 cells assessed as ((2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4046687

Name: Drug metabolism assessed as CES1 (unknown origin)-mediated monophosphate formation af...
Source: ChEMBL
Target: Liver carboxylesterase 1
External Id: CHEMBL4046685

Name: Drug metabolism assessed as CatA (unknown origin)-mediated monophosphate formation af...
Source: ChEMBL
Target: Lysosomal protective protein
External Id: CHEMBL4046686

Name: Antiviral activity against HCV genotype 1b Con1 expressing NS3 protease infected in h...
Source: ChEMBL
Target: Hepacivirus hominis
External Id: CHEMBL4046663

Name: Drug metabolism assessed as CYP3A5 (unknown origin)-mediated (R)-2-((R)-(((2R,3R,4R,5...
Source: ChEMBL
Target: Cytochrome P450 3A5
External Id: CHEMBL4046693

Name: Antiviral activity against HCV assessed as reduction in viral replication by measurin...
Source: ChEMBL
Target: Hepacivirus hominis
External Id: CHEMBL5108743

Name: Drug metabolism assessed as CES1 (unknown origin)-mediated monophosphate formation af...
Source: ChEMBL
Target: Liver carboxylesterase 1
External Id: CHEMBL4046684

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Uprifosbuvir

10275

UNII:JW31KPS26S

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Product Name: Uprifosbuvir
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Purity: 98.0%
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Use of Uprifosbuvir

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Uprifosbuvir Biological Activity

Chemical & Physical Properties

UprifosbuvirBioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.