Z-Ala-Ala-Asn-AMC
Modify Date: 2024-01-08 12:33:01
Z-Ala-Ala-Asn-AMC structure
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Common Name | Z-Ala-Ala-Asn-AMC | ||
|---|---|---|---|---|
| CAS Number | 149697-16-5 | Molecular Weight | 565.57400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H30N4O9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Z-Ala-Ala-Asn-AMCZ-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC[1]. |
| Name | z-ala-ala-asn-amc |
|---|---|
| Synonym | More Synonyms |
| Description | Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC[1]. |
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| Related Catalog | |
| In Vitro | The first legumain fluorogenic substrate Cbz-Ala-Ala-Asn-AMC based on the P3-P2-P1 sequence Ala-Ala-Asn. The synthetic substrate Cbz-Ala-Ala-Asn-AMC is effectively cleaved by S. mansoni legumain and human legumain with Kms of 90 and 80 uM respectively[2][3]. |
| References |
[2]. James C. Powers, et al. Propenoyl hydrazides. US7482379B2. |
| Molecular Formula | C28H30N4O9 |
|---|---|
| Molecular Weight | 565.57400 |
| Exact Mass | 565.21700 |
| PSA | 198.93000 |
| LogP | 3.16570 |
| z-ala-ala-asn-mca |
| benzyloxycarbonyl-l-alanyl-l-alanyl-l-asparagine 4-methylcoumaryl-7-amide |
| z-aan-amc |