4-(((2S,4S)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid

Modify Date: 2024-01-04 11:16:56

4-(((2S,4S)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid Structure
4-(((2S,4S)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid structure
Common Name 4-(((2S,4S)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid
CAS Number 149709-63-7 Molecular Weight 411.491
Density 1.2±0.1 g/cm3 Boiling Point 656.9±55.0 °C at 760 mmHg
Molecular Formula C24H29NO5 Melting Point N/A
MSDS N/A Flash Point 351.1±31.5 °C

 Use of 4-(((2S,4S)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid


2S,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure.

 Names

Name 4-{[(2S,4S)-1-(4-Biphenylyl)-5-ethoxy-4-methyl-5-oxo-2-pentanyl]amino}-4-oxobutanoic acid
Synonym More Synonyms

  Biological Activity

Description 2S,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure.
Related Catalog
References

[1]. Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44(4):554-9.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 656.9±55.0 °C at 760 mmHg
Molecular Formula C24H29NO5
Molecular Weight 411.491
Flash Point 351.1±31.5 °C
Exact Mass 411.204559
LogP 3.96
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.549
Storage condition 2-8℃

 Synonyms

[1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, α-ethyl ester, (αS,γS)-
4-{[(2S,4S)-1-(4-Biphenylyl)-5-ethoxy-4-methyl-5-oxo-2-pentanyl]amino}-4-oxobutanoic acid
4-(((2S,4S)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid
LCZ696 impurity 17
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4-(((2S,4S)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid suppliers


Price: $552/10mM*1mLinDMSO

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