(D-Phe12,Nle21.38,α-Me-Leu37)-CRF (12-41) (human, rat) trifluoroacetate salt

Modify Date: 2024-01-19 11:44:59

(D-Phe12,Nle21.38,α-Me-Leu37)-CRF (12-41) (human, rat) trifluoroacetate salt structure	Common Name	(D-Phe12,Nle21.38,α-Me-Leu37)-CRF (12-41) (human, rat) trifluoroacetate salt
	CAS Number	150646-45-0	Molecular Weight	3553.124
	Density	1.4±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₅₉H₂₆₇N₄₉O₄₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (D-Phe12,Nle21.38,α-Me-Leu37)-CRF (12-41) (human, rat) trifluoroacetate salt

(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) is a CRF antagonist. (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) prevents the IL-1a induced Luteinizing hormone (LH) inhibition[1].

Name	D-Phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-α-glutamyl-L-valyl-L-leucyl-L-α-glutamyl-L-norleucyl-L-alanyl-L-arginyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-leucyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-alanyl-L-histidyl-L-seryl-L-asparaginyl-L-arginyl-L-lysyl-2-methyl-L-leucyl-L-norleucyl-L-α-glutamyl-L-isoleucyl-L-isoleucinamide
Synonym	More Synonyms

Description	(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) is a CRF antagonist. (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) prevents the IL-1a induced Luteinizing hormone (LH) inhibition[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> CRFR
References	[1]. Feng YJ, et al. An inhibitory effects of interleukin-1a on basal gonadotropin release in the ovariectomized rhesus monkey: reversal by a corticotropin-releasing factor antagonist. Endocrinology. 1991 Apr;128(4):2077-82.

Density	1.4±0.1 g/cm3
Molecular Formula	C₁₅₉H₂₆₇N₄₉O₄₃
Molecular Weight	3553.124
Exact Mass	3551.021240
LogP	-4.34
Index of Refraction	1.644

D-Phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-α-glutamyl-L-valyl-L-leucyl-L-α-glutamyl-L-norleucyl-L-alanyl-L-arginyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-leucyl-L-alanyl-L-gluta minyl-L-glutaminyl-L-alanyl-L-histidyl-L-seryl-L-asparaginyl-L-arginyl-L-lysyl-2-methyl-L-leucyl-L-norleucyl-L-α-glutamyl-L-isoleucyl-L-isoleucinamide

L-Isoleucinamide, D-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-α-glutamyl-L-valyl-L-leucyl-L-α-glutamyl-L-norleucyl-L-alanyl-L-arginyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-leucy l-L-alanyl-L-glutaminyl-L-glutaminyl-L-alanyl-L-histidyl-L-seryl-L-asparaginyl-L-arginyl-L-lysyl-2-methyl-L-leucyl-L-norleucyl-L-α-glutamyl-L-isoleucyl-

(D-Phe12,Nle21.38,α-Me-Leu37)-CRF (12-41) (human, rat) trifluoroacetate salt

Use of (D-Phe12,Nle21.38,α-Me-Leu37)-CRF (12-41) (human, rat) trifluoroacetate salt

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Biological Activity

Chemical & Physical Properties

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