O,O,S-trimethyl phosphorothiate

Modify Date: 2026-07-01 22:17:36

O,O,S-trimethyl phosphorothiate Structure
O,O,S-trimethyl phosphorothiate structure
 Common Name O,O,S-trimethyl phosphorothiate
CAS Number 152-20-5 Molecular Weight 156.14100
Density 1.211g/cm3 Boiling Point 169ºC at 760mmHg
Molecular Formula C3H9O3PS Melting Point N/A
MSDS N/A Flash Point 56ºC

Summary: O,O,S-trimethyl phosphorothiate, also known as [methoxy(methylsulfanyl)phosphoryl]oxymethane, molecular formula C3H9O3PS, molecular weight 156.14100. For research-use only, not for medical or clinical usage.

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name [methoxy(methylsulfanyl)phosphoryl]oxymethane
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.211g/cm3
Boiling Point 169ºC at 760mmHg
Molecular Formula C3H9O3PS
Molecular Weight 156.14100
Flash Point 56ºC
Exact Mass 156.00100
PSA 70.64000
LogP 1.75030
InChIKey WTUNGUOZHBRADH-UHFFFAOYSA-N
SMILES COP(=O)(OC)SC

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TG3880000
CHEMICAL NAME :
Phosphorothioic acid, O,O,S-trimethyl ester
CAS REGISTRY NUMBER :
152-20-5
BEILSTEIN REFERENCE NO. :
1702881
LAST UPDATED :
199612
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C3-H9-O3-P-S
MOLECULAR WEIGHT :
156.15
WISWESSER LINE NOTATION :
1SPO&O1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Blood - hemorrhage Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 27,463,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
51 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - antipsychotic Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 51,221,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
45 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - muscle contraction or spasticity Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
DTESD7 52 Vanderbilt Ave., New York, NY 10017) V.1-15, 1977-87. Discontinued 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977- Volume(issue)/page/year: 8,631,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
38 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Skin and Appendages - hair
REFERENCE :
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year: 24,251,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ACPMAP Actualites Pharmacologiques. (Paris, France) No.1-33, 1949-81. For publisher information, see JNPHAG. Volume(issue)/page/year: 16,7,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
123 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - muscle contraction or spasticity Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
DTESD7 52 Vanderbilt Ave., New York, NY 10017) V.1-15, 1977-87. Discontinued 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977- Volume(issue)/page/year: 8,631,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 7,481,1981 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
28 mg/kg
SEX/DURATION :
female 19-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - respiratory system
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 63,331,1989
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2500 ug/kg
SEX/DURATION :
female 20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 61,378,1988
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
40 mg/kg
SEX/DURATION :
female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 32,185,1986
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
40 mg/kg
SEX/DURATION :
female 20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 61,378,1988
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
10 mg/kg
SEX/DURATION :
female 20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - respiratory system
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 61,378,1988

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

HS Code 2920190090

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2920190090
Summary 2920190090 other thiophosphoric esters (phosphorothioates) and their salts; their halogenated, sulphonated, nitrated or nitrosated derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

thiophosphoric acid O,O',S-trimethyl ester
O,O,S-trimethyl phosphorothiate
8000 Bis HC
phosphorothioic acid O,O,S-trimethyl ester
O,O,S-Trimethyl phosphorothioate
Dimethylthiomethylphosphate
Thiophosphorsaeure-O,O',S-trimethylester
Trimethyl phosphorothioate
O,O,S-trimethyl thiophosphate
HC7901

 O,O,S-trimethyl phosphorothiate | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the boiling point of [methoxy(methylsulfanyl)phosphoryl]oxymethane?
A: Boiling point of [methoxy(methylsulfanyl)phosphoryl]oxymethane is 169ºC at 760mmHg.
Q: What is the molecular weight of [methoxy(methylsulfanyl)phosphoryl]oxymethane?
A: Molecular weight of [methoxy(methylsulfanyl)phosphoryl]oxymethane is 156.14100.
Q: What English synonyms does [methoxy(methylsulfanyl)phosphoryl]oxymethane have?
A: English synonyms of [methoxy(methylsulfanyl)phosphoryl]oxymethane: thiophosphoric acid O,O',S-trimethyl ester, O,O,S-trimethyl phosphorothiate, 8000 Bis HC, phosphorothioic acid O,O,S-trimethyl ester, O,O,S-Trimethyl phosphorothioate, Dimethylthiomethylphosphate, Thiophosphorsaeure-O,O',S-trimethylester, Trimethyl phosphorothioate, O,O,S-trimethyl thiophosphate, HC7901.
Q: What is the CAS number of [methoxy(methylsulfanyl)phosphoryl]oxymethane?
A: CAS number of [methoxy(methylsulfanyl)phosphoryl]oxymethane is 152-20-5.
Q: What is the InChIKey of [methoxy(methylsulfanyl)phosphoryl]oxymethane?
A: InChIKey of [methoxy(methylsulfanyl)phosphoryl]oxymethane is WTUNGUOZHBRADH-UHFFFAOYSA-N.
Q: What is the LogP of [methoxy(methylsulfanyl)phosphoryl]oxymethane?
A: LogP of [methoxy(methylsulfanyl)phosphoryl]oxymethane is 1.75030.
Q: What are the upstream materials of [methoxy(methylsulfanyl)phosphoryl]oxymethane?
A: Related upstream materials(CAS) of [methoxy(methylsulfanyl)phosphoryl]oxymethane: 74-88-4;96-36-6;67-68-5;67-56-1;2953-29-9;65960-94-3;10265-92-6;152-18-1.
Q: What are the downstream products of [methoxy(methylsulfanyl)phosphoryl]oxymethane?
A: Related downstream products(CAS) of [methoxy(methylsulfanyl)phosphoryl]oxymethane: 115-10-6;75-75-2;813-78-5;690-49-3;82452-43-5;82452-57-1;3711-50-0;677-24-7;2181-42-2;32586-90-6.
Q: What is the molecular formula of [methoxy(methylsulfanyl)phosphoryl]oxymethane?
A: Molecular formula of [methoxy(methylsulfanyl)phosphoryl]oxymethane is C3H9O3PS.
Q: What is the English name of [methoxy(methylsulfanyl)phosphoryl]oxymethane?
A: The English name of [methoxy(methylsulfanyl)phosphoryl]oxymethane is [methoxy(methylsulfanyl)phosphoryl]oxymethane.

 O,O,S-trimethyl phosphorothiatefactory

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