Nalfurafine hydrochloride
Modify Date: 2024-01-02 18:34:07
Nalfurafine hydrochloride structure
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Common Name | Nalfurafine hydrochloride | ||
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| CAS Number | 152658-17-8 | Molecular Weight | 513.025 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H33ClN2O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Nalfurafine hydrochlorideNalfurafine hydrochloride is a κ-opioid agonist and an anti-itch drug approved in Japan. |
| Name | Nalfurafine Hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Nalfurafine hydrochloride is a κ-opioid agonist and an anti-itch drug approved in Japan. |
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| Related Catalog | |
| In Vivo | Nalfurafine (subcutaneous injection; 0.015 mg/kg) combines with EOM-salvinorin-B produces spinal antinociception equivalent to 5 mg/kg, it also enhances the supraspinal analgesic effect of 5 mg/kg morphine[1]. Nalfurafine (subcutaneous injection; 4 μg/kg) causes a dose-dependent increase of the inhibition of the acetic acid-induced abdominal constriction,and the inhibition of the abdominal constriction reaches its peak 30 min after injection, gradually declined and returned to the pre-injection level 4 hr after[2]. Animal Model: Male and Female C57BL/6J mice[1] Dosage: 0.015 mg/kg Administration: Subcutaneous injection Result: Had the potential for enhancing the therapeutic potential of MOR-targeting analgesics, such as morphine. |
| References |
| Molecular Formula | C28H33ClN2O5 |
|---|---|
| Molecular Weight | 513.025 |
| Exact Mass | 512.207825 |
| PSA | 86.38000 |
| LogP | 3.82960 |
| Storage condition | -20℃ |
| Nalfurafine hydrochloride |
| (2E)-N-[(5α,6β)-17-(Cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6-yl]-3-(3-furyl)-N-methylacrylamide hydrochloride (1:1) |
| 2-Propenamide, N-[(5α,6β)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]-3-(3-furanyl)-N-methyl-, (2E)-, hydrochloride (1:1) |
| (E)-N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide,hydrochloride |
| Nalfurafine (hydrochloride) |