Cyclo(-Gly-His)

Modify Date: 2025-08-25 21:52:00

Cyclo(-Gly-His) Structure
Cyclo(-Gly-His) structure
Common Name Cyclo(-Gly-His)
CAS Number 15266-88-3 Molecular Weight 194.19
Density N/A Boiling Point N/A
Molecular Formula C8H10N4O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Cyclo(-Gly-His)


Cyclo(Gly-His) is a liposome-encapsulated cyclic dipeptide with antimicrobial and anticancer activity. Cyclo(Gly-His) has cytotoxicity for HeLa and MCF-7 cell with IC50 values of 1.699 mM and 0.358 mM, respectively. Cyclo(Gly-His) can be used for the research of drug delivery systems[1].

 Names

Name Cyclo(-Gly-His)
Synonym More Synonyms

 Cyclo(-Gly-His) Biological Activity

Description Cyclo(Gly-His) is a liposome-encapsulated cyclic dipeptide with antimicrobial and anticancer activity. Cyclo(Gly-His) has cytotoxicity for HeLa and MCF-7 cell with IC50 values of 1.699 mM and 0.358 mM, respectively. Cyclo(Gly-His) can be used for the research of drug delivery systems[1].
Related Catalog
Target

IC50: 1.699 mM (HeLa cell) and 0.358 mM (MCF-7 cell)[1].

In Vitro Cyclo(Gly-His) 对 HeLa 和 MCF-7 细胞具有细胞毒性,IC50 值分别为 1.699 mM 和 0.358 mM[1]。
References

[1]. Kilian G, et al. Anticancer activity of the liposome-encapsulated cyclic dipeptides, cyclo(His-Gly) and cyclo(His-Ala). Pharmazie. 2013;68(3):207-211.  

 Chemical & Physical Properties

Molecular Formula C8H10N4O2
Molecular Weight 194.19
Exact Mass 194.08000
PSA 86.88000

 Safety Information

HS Code 2933990090

 Synthetic Route

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Cyclo(-Gly-His) Structure

Cyclo(-Gly-His)

CAS#:15266-88-3

Literature: Arena, Giuseppe; Impellizzeri, Giuseppe; Maccarrone, Giuseppe; Pappalardo, Giuseppe; Sciotto, Domenico; Rizzarelli, Enrico Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1992 , # 3 p. 371 - 376

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Cyclo(-Gly-His) Structure

Cyclo(-Gly-His)

CAS#:15266-88-3

Literature: Arena, Giuseppe; Impellizzeri, Giuseppe; Maccarrone, Giuseppe; Pappalardo, Giuseppe; Sciotto, Domenico; Rizzarelli, Enrico Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1992 , # 3 p. 371 - 376

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

(S)-3-(1H-Imidazol-4-ylmethyl)-2,5-piperazinedione
CYCLO(GLY-L-HIS)
cyclo-Gly-His
cyclo-(glycyl-L-histidyl)
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