oxypertine
Modify Date: 2026-07-08 20:57:15
oxypertine structure
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Common Name | oxypertine | ||
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| CAS Number | 153-87-7 | Molecular Weight | 379.49500 | |
| Density | 1.157g/cm3 | Boiling Point | 555.5ºC at 760 mmHg | |
| Molecular Formula | C23H29N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 289.8ºC | |
Use of oxypertineOxypertine is a neuroprotective agent. Oxypertine can be used in the research of neurological conditions, such as anxiety and schizophrenia[1][2][3]. |
| Name | oxypertine |
|---|---|
| Synonym | More Synonyms |
| Description | Oxypertine is a neuroprotective agent. Oxypertine can be used in the research of neurological conditions, such as anxiety and schizophrenia[1][2][3]. |
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| Related Catalog | |
| In Vitro | Oxypertine (0.44 nM-26 μM, 15 min) antagonizes dopamine and 5-HT induced contractions of the rat isolated vas deferens[1]. Oxypertine (8.8 nM, 15 min) reduces the contractions evoked by transmural stimulation of the vas deferens[1]. |
| In Vivo | Oxypertine (10 and 35 mg/kg, i.p.) causes an obvious dose-related depletion in the levels of norepinephrine (NE), dopamine (DA) and 5-hydroxytryptamine (5-HT) in various discrete regions of the rat brain[2]. Oxypertine (0.625-20 mg/kg, i.p.) inhibits stereotyped behaviour induced by both amphetamine and apomorphine in rats[3]. Animal Model: Mice with chronic restraint stress[2] Dosage: 10, 35 mg/kg Administration: Intraperitoneal injection (i.p.) Result: Increased the level of homovanillic acid in three discrete regions, i.e., the cortex, striatum and mid-brain. Inhibited Apomorphine-induced stereotypy. Animal Model: Mice with stereotyped behaviour induced by amphetamine (5.0 mg/kg i.p.) and apomorphine (1.0 mg/kg, s.c.)[3] Dosage: 0.625-20 mg/kg Administration: Intraperitoneal injection (i.p.) Result: Reduced the content of dopamine in the striatum but increased the concentrations of homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC). |
| Density | 1.157g/cm3 |
|---|---|
| Boiling Point | 555.5ºC at 760 mmHg |
| Molecular Formula | C23H29N3O2 |
| Molecular Weight | 379.49500 |
| Flash Point | 289.8ºC |
| Exact Mass | 379.22600 |
| PSA | 40.73000 |
| LogP | 3.86110 |
| Vapour Pressure | 2.22E-12mmHg at 25°C |
| Index of Refraction | 1.614 |
| InChIKey | XCWPUUGSGHNIDZ-UHFFFAOYSA-N |
| SMILES | COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| RIDADR | UN 3249 |
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| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2933990090 |
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Name: Compound was evaluated for inhibition of rat Gabra1 in an in vitro assay with cellula...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-1
External Id: CHEMBL5291801
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Name: Agonist activity at human GABRA1 in an in vitro cell-based assay measured by fluoresc...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit gamma-2
External Id: CHEMBL5291796
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Name: Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-1
External Id: CHEMBL5291798
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|
Name: Antagonist activity at human GABRA1 in an in vitro cell-based assay measured by fluor...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit gamma-2
External Id: CHEMBL5291797
|
|
Name: Binding affinity towards human EDNRA in an in vitro assay with cellular components me...
Source: ChEMBL
Target: Endothelin-1 receptor
External Id: CHEMBL5291785
|
|
Name: Binding affinity towards human DRD2 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: D(2) dopamine receptor
External Id: CHEMBL5291781
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|
Name: Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resol...
Source: ChEMBL
Target: D(1A) dopamine receptor
External Id: CHEMBL5291777
|
|
Name: Antagonist activity at human CNR1 in an in vitro cell-based assay measured by fluores...
Source: ChEMBL
Target: Cannabinoid receptor 1
External Id: CHEMBL5291772
|
|
Name: Agonist activity at human CNR1 in an in vitro cell-based assay measured by fluorescen...
Source: ChEMBL
Target: Cannabinoid receptor 1
External Id: CHEMBL5291771
|
|
Name: Binding affinity towards human MC3R in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Melanocortin receptor 3
External Id: CHEMBL5291831
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| Integrin |
| EINECS 205-818-3 |
| Opertil |
| Equipertine |
| Forit |