oxypertine

Modify Date: 2025-08-25 20:56:28

oxypertine Structure
oxypertine structure
Common Name oxypertine
CAS Number 153-87-7 Molecular Weight 379.49500
Density 1.157g/cm3 Boiling Point 555.5ºC at 760 mmHg
Molecular Formula C23H29N3O2 Melting Point N/A
MSDS N/A Flash Point 289.8ºC

 Use of oxypertine


Oxypertine is a neuroprotective agent. Oxypertine can be used in the research of neurological conditions, such as anxiety and schizophrenia[1][2][3].

 Names

Name oxypertine
Synonym More Synonyms

 oxypertine Biological Activity

Description Oxypertine is a neuroprotective agent. Oxypertine can be used in the research of neurological conditions, such as anxiety and schizophrenia[1][2][3].
Related Catalog
In Vitro Oxypertine (0.44 nM-26 μM, 15 min) antagonizes dopamine and 5-HT induced contractions of the rat isolated vas deferens[1]. Oxypertine (8.8 nM, 15 min) reduces the contractions evoked by transmural stimulation of the vas deferens[1].
In Vivo Oxypertine (10 and 35 mg/kg, i.p.) causes an obvious dose-related depletion in the levels of norepinephrine (NE), dopamine (DA) and 5-hydroxytryptamine (5-HT) in various discrete regions of the rat brain[2]. Oxypertine (0.625-20 mg/kg, i.p.) inhibits stereotyped behaviour induced by both amphetamine and apomorphine in rats[3]. Animal Model: Mice with chronic restraint stress[2] Dosage: 10, 35 mg/kg Administration: Intraperitoneal injection (i.p.) Result: Increased the level of homovanillic acid in three discrete regions, i.e., the cortex, striatum and mid-brain. Inhibited Apomorphine-induced stereotypy. Animal Model: Mice with stereotyped behaviour induced by amphetamine (5.0 mg/kg i.p.) and apomorphine (1.0 mg/kg, s.c.)[3] Dosage: 0.625-20 mg/kg Administration: Intraperitoneal injection (i.p.) Result: Reduced the content of dopamine in the striatum but increased the concentrations of homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC).

 Chemical & Physical Properties

Density 1.157g/cm3
Boiling Point 555.5ºC at 760 mmHg
Molecular Formula C23H29N3O2
Molecular Weight 379.49500
Flash Point 289.8ºC
Exact Mass 379.22600
PSA 40.73000
LogP 3.86110
Vapour Pressure 2.22E-12mmHg at 25°C
Index of Refraction 1.614

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NL7170000
CHEMICAL NAME :
Indole, 5,6-dimethoxy-2-methyl-3-(2-(4-phenyl-1-piperazinyl)e thyl)-
CAS REGISTRY NUMBER :
153-87-7
BEILSTEIN REFERENCE NO. :
0899339
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C23-H29-N3-O2
MOLECULAR WEIGHT :
379.55
WISWESSER LINE NOTATION :
T56 BMJ C1 GO1 HO1 D2- AT6N DNTJ DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,154,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,154,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
154 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 26,186,1966

 Safety Information

RIDADR UN 3249
Packaging Group III
Hazard Class 6.1(b)
HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Integrin
EINECS 205-818-3
Opertil
Equipertine
Forit
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