4-Boc-amino-2,2-dimethylbutyric acid

Modify Date: 2024-01-09 14:18:45

4-Boc-amino-2,2-dimethylbutyric acid Structure
4-Boc-amino-2,2-dimethylbutyric acid structure
Common Name 4-Boc-amino-2,2-dimethylbutyric acid
CAS Number 153039-17-9 Molecular Weight 231.28900
Density 1.065g/cm3 Boiling Point 369.9ºC at 760mmHg
Molecular Formula C11H21NO4 Melting Point N/A
MSDS N/A Flash Point 177.5ºC

 Use of 4-Boc-amino-2,2-dimethylbutyric acid


4-Boc-amino-22-dimethylbutyric acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 4-boc-amino-2,2-dimethylbutyric acid
Synonym More Synonyms

 4-Boc-amino-2,2-dimethylbutyric acid Biological Activity

Description 4-Boc-amino-22-dimethylbutyric acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.065g/cm3
Boiling Point 369.9ºC at 760mmHg
Molecular Formula C11H21NO4
Molecular Weight 231.28900
Flash Point 177.5ºC
Exact Mass 231.14700
PSA 75.63000
LogP 2.40290
Vapour Pressure 1.74E-06mmHg at 25°C
Index of Refraction 1.463

 Synonyms

1-Boc-3-Carbamoylpiperazine
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