Pratosartan

Modify Date: 2024-01-18 15:54:29

Pratosartan Structure
Pratosartan structure
Common Name Pratosartan
CAS Number 153804-05-8 Molecular Weight 426.51400
Density 1.321g/cm3 Boiling Point 692.92ºC at 760 mmHg
Molecular Formula C25H26N6O Melting Point N/A
MSDS N/A Flash Point 372.864ºC

 Use of Pratosartan


Pratosartan is a selective angiotensin II receptor antagonist.

 Names

Name pratosartan
Synonym More Synonyms

 Pratosartan Biological Activity

Description Pratosartan is a selective angiotensin II receptor antagonist.
Related Catalog
Target

angiotensin II receptor[1]

In Vitro Pratosartan, which is an orally active angiotensin II (AII) antagonist, exhibiting selective and potent antagonistic activity to AT1 subtype[1]. Pratosartan is a new angiotensin II type 1 receptor blocker. Pratosartan is an effective and well tolerated antihypertensive drug, and may has beneficial effect on hypertensive patients with some metabolic disorders[2].
References

[1]. Sonegawa M, et al. Synthesis and pharmacological activity of the metabolites of Pratosartan. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):782-7.

[2]. Ogihara T, et al. Clinical efficacy of a new angiotensin II type 1 receptor blocker, pratosartan, in hypertensive patients. Hypertens Res. 2008 Feb;31(2):281-7.

 Chemical & Physical Properties

Density 1.321g/cm3
Boiling Point 692.92ºC at 760 mmHg
Molecular Formula C25H26N6O
Molecular Weight 426.51400
Flash Point 372.864ºC
Exact Mass 426.21700
PSA 89.35000
LogP 4.64010
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.701
Storage condition 2-8℃

 Synonyms

Pratosartan (JAN/INN)
UNII-66VLQ6E6DL
2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-5,6,7,8-tetrahydrocyclohepta[d]imidazol-4-one
KD 3-671
KT3-671
Pratosartan
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